摘要
目的评价间苯三酚、地塞米松及联合用药在输尿管镜碎石术中临床疗效。方法排除泌尿系严重感染、泌尿系结核和先天性泌尿系畸形等病例,回顾性分析124例患者临床资料,其中对照组(n=29),间苯三酚组(n=32)、地塞米松组(n=29)及联合用药组(n=34),对照组常规行输尿管镜碎石术,其余3组在输尿管镜进镜前15 min分别静脉注射间苯三酚80 mg、地塞米松10 mg、间苯三酚80 mg+地塞米松10 mg,分析各组手术并发症、药物毒副作用、手术时间、术后肉眼血尿时间和结石排净率。结果所有患者均顺利完成手术,所有药物治疗组未出现明显毒副作用;在手术时间及术后肉眼血尿时间上,地塞米松组与对照组比较差异无统计学意义,间苯三酚组及联合用药组均低于对照组(P<0.05),组间比较,联合用药组低于间苯三酚组(P<0.05);在结石排净率上,间苯三酚组、地塞米松组与对照组比较差异无统计学意义(P>0.05),联合用药组疗效优于对照组(P=0.017)。结论输尿管镜碎石术中联合使用间苯三酚及地塞米松,可明显缩短手术时间及术后肉眼血尿时间,提高结石清除率。
Objective To evaluate the clinical effect of Phloroglucinol combined with Dexamethasone in ureteroscopy lithotripsy. Methods Patients with severe urinary infection, urinary tract tuberculosis, congenital urinary tract malformation were excluded. The clinical data of 124 patients with ureteral calculus was retrospectively analyzed, Group control with 29 patients who underwent conventional ureteroscopy lithotripsy, 32 patients were given Phloroglucinol （80 mg） as Group phloroglucinol, 29 patients were given Dexamethasone （10 mg） as Group Dexamethasone, 34 patients were given combination drugs of Phloroglucinol （80 mg） plus Dexamethasone （10 mg） as Group combination therapy, intravenously 15 min prior to surgery, respectively. The surgical complication, sideeffects, operation time, duration of postoperative hematuria, and expulsion rate were recorded. Results All surgeries were accomplished successfully, and none severe side-effects were observed among these cases. In comparison of operation time and duration of postoperative hematuria, there were no significant difference between group Dexamethasone and group control, and both group Phloroglucinol and group combination therapy were better than that of group control （P 〈 0.05）, furthermore, group combination therapy was better than group phloroglucinol （P 〈 0.05）. In comparison of the expulsion rate, there were no significant difference between group control and group Phloroglucinol or group Dexamethasone （P 〉 0.05）, however, group combination therapy is better than that of group control （P = 0.017）. Conclusion Combined treatment with Phloroglucinol and Dexamethasone in ureteroscopy lithotripsy would shorten the operation time and duration of postoperative hematuria significantly, and improve the expulsion rate eventually.
出处
《中国内镜杂志》
2018年第1期1-4,共4页
China Journal of Endoscopy
基金
国家自然科学基金(No:81402379)
江苏省"六大人才高峰"项目(No:WSW-166)
江苏省卫计委科研项目(No:Z201526)
江苏省青年医学人才项目(No:QNRC2016472)
关键词
输尿管镜
手术治疗
间苯三酚
地塞米松
ureteroscope
surgical treatment
Phloroglucinol
Dexamethasone
