摘要
目的：观察西黄丸联合TC化疗方案对晚期乳腺癌患者临床疗效及生活质量的影响。方法：253例晚期乳腺癌患者随机分为两组。其中观察组128例,采用西黄丸＋TC化疗方案;对照组125例,采用TC化疗方案。治疗后评价两组患则的临床疗效,比较两组患者治疗前后肿瘤标记物CEA（癌胚抗原）、CA125表达水平及KPS评分（卡氏评分）,并记录与用药相关的不良反应发生情况。结果：观察组患者总缓解率为52.34%,高于对照组的39.20%,差异具有统计学意义（P〈0.05）;治疗后,两组患者CEA、CA125表达均降低,差异具有统计学意义（P〈0.05）;组间比较,观察组CEA、CA125表达水平均低于对照组,差异具有统计学意义（P〈0.05）;治疗后,两组患者KPS评分均显著上升,且观察组升高幅度高于对照组,差异均具有统计学意义（P〈0.05）;观察组白细胞下降、脱发发生率于对照组水平相当,差异不具有统计学意义（P〉0.05）,恶心呕吐及口苦发生率显著低于对照组,差异具有统计学意义（P〈0.05）。结论：西黄丸配合TC化疗方案能够提高晚期乳腺癌患者的临床疗效及生存质量,降低血清肿瘤标志物水平和不良反应发生率,值得在临床工作中推广使用。
Objective： To study the correlation between strategies of endocrine therapy and the survival of advanced breast cancer patients with the treatment of TCM. Methods： 253 patients with advanced Breast Cancer were randomly divided into two groups. There were 128 patients in the observation group,using the proposed prescription ＋ TC chemotherapy regimens,and 125 patients in control group used TC chemotherapy regimens. After treatment,we made a evaluation of the clinical effect and compared the levels of CEA,CA125 and KPS before and after treatment. We made a record of the adverse events in both groups. Results： The observation group had a better clinical effect compared with control group. After treatment,the levels of CEA and CA125 expressions were significantly reduced in both groups. CEA and CA125 expression levels in observation group were lower than those of the control group（ P 〈 0. 05）. After treatment,two groups’ KPS scores were significantly increased and the proportion was larger in the observation group（ P 〈 0. 05）. The incidence of nausea and bitter mouth was significantly lower than the control group’s and the difference had statistical significance（ P 〈 0. 05）. Conclusion： Chinese medicine cooperating with TC chemotherapy can improve the clinical curative effect of patients with advanced breast cancer and survival quality,can also can lower the levels of serum tumor markers and the incidence of adverse reactions,which is worthy of promotion in clinical work.
出处
《中华中医药学刊》
CAS
北大核心
2018年第1期232-234,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药科技计划项目(2017ZA019)
关键词
西黄丸
TC化疗
晚期乳腺癌
临床疗效
肿瘤标记物
生活质量
不良反应
Xihuang Pill
TC chemotherapy
advanced breast cancer
clinical curative effect
tumor markers
quality of life
adverse events
