摘要
目的探讨地拉罗司与去铁胺治疗重型β-地中海贫血铁过载患儿的临床疗效。方法收集重型β-地中海贫血铁过载患儿47例,按照不同治疗方案分为两组:观察组26例给予地拉罗司治疗,对照组21例给予去铁胺治疗。治疗12个月后比较两组患儿的治疗效果、血清铁蛋白(SF)、不良反应以及心脏、肝脏磁共振成像(MRI)T2~*检查结果。结果治疗12个月后,两组总有效率比较差异无统计学意义(P>0.05);观察组总控制率明显高于对照组,差异有统计学意义(P<0.05);观察组心脏、肝脏T2~*值明显高于对照组,差异有统计学意义(P<0.05);观察组在治疗12个月后SF水平明显低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论地拉罗司治疗重型β-地中海贫血铁过载的近期效果明显优于去铁胺,明显降低了SF水平,尤其对肝脏去铁效果更为明显,且减少了不良反应的发生,值得临床重视。
Objective To investigate the effect of deferasirox and deferoxamine in treatment of iron overload in children with β - thalasse-mia major,and to provide reference for clinical treatment. Methods 47 β - thalassemia major children with iron overload in our hospital were collected,according to different treatment method,the patients were divided into two groups. The observation group （n = 26）was treated with De-ferasirox,the control group （n = 21）was treated with deferoxamine. After 12 months of treatment,the therapeutic effect,serum ferritin （SF）,adverse reaction and cardiac,liver MRI T2＊ value were compared between the two groups. Results After 12 months of treatment,there was no significant difference in total effective rate between the two groups （P 〉 0. 05）. The total control rate of the observation group was significantly higher than that of the control group,the difference was statistically significant （P 〈 0. 05）. The cardiac,liver T2＊ value in the observation group was significantly higher than that in the control group,the difference was statistically significant （P 〈 0. 05）. The level of SF in the obser-vation group was significantly lower than that in the control group after 12 months of treatment,and the difference was statistically significant （P〈 0. 05）. The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically sig-nificant （P 〈 0. 05）. Conclusion The recent effect of deferasirox treatment of beta thalassemia major iron overload is significantly better than that of deferoxamine,significantly reduce the level of SF,in particular. The effect of iron removal is more obvious,and it can reduce the occur-rence of adverse reactions. Therefore,it is worthy of clinical attention.
出处
《临床和实验医学杂志》
2018年第1期67-70,共4页
Journal of Clinical and Experimental Medicine
