摘要
组织病理诊断表明:本院外阴硬化萎缩性苔藓(硬萎)81例(82块标本)中充份发展的硬萎64例(65块标本),其表现为表皮萎缩,基底层液化变性,真皮浅层胶原纤维均质性变性,其下方有炎性细胞浸润。早期硬萎4例,表现为表皮萎缩,钉突消失,真皮浅层沿着表皮与真皮交界处有密集或带状淋巴细胞浸润。硬萎伴发慢性单纯苔藓13例,表现为表皮各层增厚,其余同充份发展的硬萎。超微结构观察:部分细胞间隙明显扩大,桥粒减少,上皮间有炎细胞浸润,基底细胞排列不规则,部分基底膜变薄;间质中胶原纤维排列紊乱,肿胀,横纹不明显。
Histopathological and ultrastructural studies of 82 skin specimen from 81 cases of Lichen sclerosus et atrophicus (LSA) are reported. Among 64 cases of fully developed LSA, 65 specimens showed atrophy of the epidermis and hydropic degeneration at the basal layer.The collagenous fibers were swollen and homogeneous n the superficial dermis with inflammatory cells infiltrating beneath the areas of collagenous homogenization. There were 4 early cases of LSA in which epithelial thinning with flattening of the rete ridges, lichenoid lymphocytes and some histiocytes in the papillary dermis and along the dermo-epidermal junction were seen. Lichen simplex chronicus superimposed upon LSA lesions was present in 13 cases showing hyperplastic epidermis, all other observations were the same as those described in fully developed LSA.By electron microscopy, the intercellular spaces in the lesions appeared dilated, particularly those near basal cells, and desmosomes were found to be fewer than normal. Some lymphocytes and neutrophilic granulocytes were seen in the epithelial basement membrane, which was thinner than that in normal samples. Collagen fibers of varying diameters were arranged irregularly and with unclear fine structures.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1991年第5期327-331,共5页
Acta Academiae Medicinae Sinicae
关键词
苔藓
胶原纤维
变性
硬化萎缩性
Lichen sclerosus et atrophicus collagen fibers homogenization
