摘要
目的:观察不同剂量瑞舒伐他汀钙联合基础治疗老年不稳定型心绞痛(UAP)患者的临床疗效,及对患者血清炎症因子的影响。方法:老年UAP患者82例随机分为低剂量组(n=40)和高剂量组(n=42)。在基础治疗外,低剂量组给予瑞舒伐他汀钙片10 mg,po,qn;高剂量组给予瑞舒伐他汀钙片20 mg,po,qn。比较两组患者治疗前及治疗3个月后血清炎症因子及血脂水平变化,观察两组疗效,心绞痛发作频率、发作时间,以及相关不良事件发生情况。结果:治疗后,两组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)水平均较治疗前明显下降,高密度脂蛋白(HDL-C)水平则较前升高(P<0.05),且高剂量组各项血脂指标均优于低剂量组(P<0.05),两组患者肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)及转化生长因子β1(TGF-β1)水平均较治疗前明显下降(P<0.05),且高剂量组明显低于低剂量组(P<0.05)。高剂量组治疗总有效率为95.43%,明显优于低剂量组的77.50%(P<0.05);且高剂量组患者的心绞痛发作频率及发作时间均少于低剂量组患者(P<0.05)。两组相关不良事件发生率差异无统计学意义(P>0.05)。结论:大剂量瑞舒伐他汀钙联合基础治疗可有效改善老年UAP患者的血脂和血清炎症因子水平,具有较好的临床疗效。
Objective： To observe the effects of rosuvastatin calcium at different doses combined with the basic treatment in elderly patients with unstable angina pectoris（ UAP）, and investigate the influence on the serum inflammatory factors. Methods： Totally 82 ca- ses of elderly patients with UAP were divided into the low dose group and the high dose group randomly. In addition to the basic treat- ment, the low dose group was given rosuvastatin calcium tablets 10mg, once per night, and the high dose group was given rosuvastatin calcium tablets 20 rag, once per night. The serum inflammatory factors and blood lipid levels of the two groups before the treatment and after 3-months treatment were compared. The therapeutic effect, frequency and duration of attack and the incidence of adverse events of the two groups were evaluated. Results ： After the treatment, the levels of TC, TG and LDL-C in both groups significantly decreased, and that of HDL-C increased （P 〈 0.05）, and the blood lipid indexes in the high dose group were better than those in the low dose group （ P 〈 0.05）. The levels of TNF-α, IL-6 and TGF-β1 decreased significantly after the treatment （ P 〈 0.05）, and level of these indexes in the high dose group were much lower than that in the low dose group （P 〈 0.05）. The total effective rate in the high dose group was 95.43%, which was much higher than that （77.50%） in the low dose group （P 〈0.05）. The frequency and duration of angina pectoris in the high dose group were both lower than those in the low dose group （P 〈 0.05）. The incidence of adverse events in the two groups showed no statistically significant difference（ P 〉 0.05 ）. Conclusion： High dose rosuvastatin calcium combined with the basic treatment can effectively improve the blood lipid levels and serum inflammatory factors in the elderly patients with UAP, which exhibits good clinical curative effect.
出处
《中国药师》
CAS
2018年第1期115-117,共3页
China Pharmacist
关键词
瑞舒伐他汀钙
不稳定型心绞痛
老年患者
血清炎症因子
血脂
疗效
Rosuvastatin calcium
Unstable angina pectoris
Elderly patients
Serum inflammatory factors
Blood lipid
Curative effect
