摘要
目的通过研究喉咽癌组织X染色体耦联锌指蛋白(Zfx)的表达,探讨Zfx在喉咽癌中的意义。方法收集手术切除后病理明确的喉咽癌组织标本(实验组)和健康人群喉咽组织标本(对照组)各47例,通过免疫组化染色分别对实验组及对照组标本中的Zfx水平进行检测,应用统计学方法对实验组和对照组标本中Zfx的表达进行分析。结果 Zfx在实验组中的阳性表达率明显高于对照组,差异有统计学意义(χ2=71.66,P<0.05)。实验组和对照组的平均光密度值差异有统计学意义(t=4.728,P<0.05),即实验组中的Zfx蛋白表达水平明显高于对照组中的Zfx蛋白表达水平。结论 Zfx在喉咽癌中存在异常高表达,极有可能在喉咽癌的发生发展过程中发挥重要的作用,可能是一个关键性的调控因子。
Objective To investigate the significance of Zfx in Hypopharyngeal Neoplasms by studying the expression of X-linked zinc-finger protein(Zfx)of Hypopharyngeal Neoplasms.Methods Hypopharyngeal carcinoma tissue specimens collected after surgical resection of the pathological diagnosis(NPC)and healthy hypopharyngeal tissue specimens(control group)47 cases by Immunohistochemistry staining respectively in hypopharyngeal carcinoma group and control group were in the levels of Zfx were measured,using statistical methods to analyze the expression of hypopharyngeal carcinoma group and control group of Zfx in the samples.Results The positive expression rate of Zfx in Hypopharyngeal Neoplasms group was significantly higher than that in control group,the difference was statistically significant(χ2=71.66,P<0.05).The mean optical density of the experimental group and the control group was statistically significant(t=4.728,P<0.05),that the level of Zfx protein expression in the Hypopharyngeal Neoplasms was significantly higher than that in the control group.Conclusion The presence of Zfx in Hypopharyngeal Neoplasms is very high and is likely to play an important role in the development and progression of Hypopharyngeal Neoplasms.It may be a key regulatory factor.
出处
《内蒙古医学杂志》
2017年第12期1409-1411,1539,共4页
Inner Mongolia Medical Journal
基金
内蒙古自治区自然科学基金面上项目(2015MS0834)
