摘要
目的 调查成年人造血干细胞移植患者不同时间点生命质量的现状,并分析其影响因素.方法 运用患者一般资料调查表、领悟社会支持量表及癌症治疗功能评价系统——骨髓移植生命质量量表,对143例接受造血干细胞移植的患者分别于入住净化仓前、移植后1个月时、移植后3个月时进行调查.结果 造血干细胞移植患者不同时间点的生命质量水平差异有统计学意义（P〈0.05）;多因素分析发现,在入仓前,影响患者生命质量的因素有：社会支持（OR=4.480,P=0.019）、居住地（OR=3.167,P=0.036）、疾病诊断（OR=0.036,P=0.042）;移植后1个月时,影响患者生命质量的因素有：社会支持（OR=3.573,P=0.018）、出仓时血小板是否重建（OR=2.735,P=0.018）及是否发生移植相关并发症（OR=0.214,P=0.016）;移植后3个月时,影响患者生命质量的因素有：社会支持（OR=9.639,P=0.000）、是否发生移植相关并发症（OR=0.167,P=0.003）.结论 造血干细胞移植患者的生命质量得分较低并呈现动态变化,社会支持是生命质量的唯一持续影响因素,这提示我们,在对造血干细胞移植患者的生命质量进行干预时,应充分重视和利用社会支持.
Objective To investigate the dynamic changes and analyze the influencing factors of quality of life （QOL） among adult patients undergoing hematopoietic stem cell transplantation （HSCT）. Methods Totally 143 HSCT patients were investigated by the common questionnaire, the Perceived Social Support Scale （PSSS） and the Functional Assessment in Cancer Therapy—Bone Marrow Transplant （FACT-BMT） before checked in the purification bin,1 month post transplantation and 3 months post transplantation. Results The QOL were different among different time points of HSCT patients （P〈0.05）. Multiple factors analysis showed that the factors before checked in the purification bin including social support （OR=4.480, P=0.019）, residence （OR=3.167, P=0.036） and disease diagnosis （OR=0.036, P=0.042）. The factors 1 month post transplantation included social support （OR=3.573, P=0.018）, whether or not the platelets were reconstructed during storage （OR=2.735, P=0.018） and whether there were transplant related complications （OR=0.214, P=0.016）. The factors 3 month post transplantation included social support （OR=9.639, P〈0.01） and whether there were transplant related complications （OR=0.167, P=0.003）. Conclusions The QOL was low among HSCT patients, and it dynamically changed at different points. Social support is the only sustainable influencing factor of quality of life. This prompts us that we should pay abundant attention on social support and use it to improve the QOL of HSCT patients.
出处
《中国实用护理杂志》
2017年第34期2646-2651,共6页
Chinese Journal of Practical Nursing
基金
苏州市科技局项目（SYSD2016086）
关键词
造血干细胞移植
生活质量
影响因素
纵向研究
Hematopoietic stem cell transplantation
Quality of life
Longitudinal studies
Influencing factors
