摘要
以2,2,6,6-四甲基哌啶氮氧自由基(TEMPO)为电催化氧化媒介,六甲基二硅胺烷(HMDS)为氮源,在室温下实现了一锅法电氧化醇类化合物为腈类化合物.采用循环伏安法和电化学原位红外光谱技术分别对TEMPO的电催化性能和一锅法电氧化历程进行了研究.在优化条件下,将该反应体系拓展到系列醇类化合物的电催化氧化中,结果表明,不同的醇类化合物,特别是苄醇,取得了较好的反应收率.基于以上研究结果提出了可能的反应机理.
One-pot electrochemical oxidation synthesis of nitriles from alcohols was developed with hexamet-hyldisilazane（ HMDS） as the nitrogen source,2,2,6,6-tetramethylpiperidinyl-1-oxy（ TEMPO） as the electrooxidation medium at the room temperature. The catalytic performance of TEMPO was studied by cyclic voltammetry,and the oxidation process was monitored by in situ FTIR analysis. Under the optimized conditions,the constant potential electrolysis of various alcohols,especially of benzylic alcohols,afforded the corresponding nitriles in moderate to excellent yields. Finally,the corresponding reaction mechanism of one-pot electrochemical oxidation of alcohols to nitriles was proposed.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2018年第1期78-84,共7页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21376224)
浙江省自然科学基金(批准号:LY17B060007)资助~~
关键词
2
2
6
6-四甲基哌啶氮氧自由基
电氧化
六甲基二硅胺烷
醇
腈
2,2,6,6-Tetramethylpiperidinyl- 1-oxy （TEMPO）
Electrooxidation
Hexamethyldisilazane（HMDS）
Alcohol
Nitrile
