摘要
目的充分利用数据库的比对功能,指导无比对样本混合分型的分析、数据库比对和比对结果的筛选。方法使用联合包含概率描述混合分型的识别力。利用联合被包含概率来估计被混合分型包含的样本的可靠性。结果混合分型的联合包含概率小于10^(-7)时具备入库比对的价值。混合分型单个基因座上能确定的等位基因大于等于2个时,增加一个额外等位基因,不会过多降低识别力。数据库检索获得多个无容差比中结果后,可以根据联合被包含概率来进行排序,快速找到最有价值样本。
Objective From the perspective of making full use of database comparison function,giving certain guidelines to analyze mixed DNA profile,compare database,screen comparison results.Methods Using CPI to describe the identification of mixed DNA profile.Using CPBI to estimate reliability of individual samples being included.Results When CPI is less than 10-7,mixed DNA Profile is worth to be compared in database.When the number of alleles at one locus is more than 2,retain an additional allele will not reduce identification too much.According to the CPBI of the included samples,we can find the most reliable sample.
出处
《中国法医学杂志》
CSCD
2017年第6期645-648,共4页
Chinese Journal of Forensic Medicine
关键词
法医物证学
STR
混合分型
数据库比对
forensic biological evidence
STR
mixed DNA profile
database comparison
