摘要
目的探讨痹祺胶囊联合玻璃酸钠治疗膝骨性关节炎的临床疗效。方法选取2016年2月—2017年2月在渭南市中心医院接受治疗的膝骨性关节炎患者82例,依据用药的差别分为对照组(41例)和治疗组(41例)。对照组关节腔内注射玻璃酸钠注射液,2 m L/次,1次/周。治疗组在对照组的基础上口服痹祺胶囊,1.2 g/次,3次/d。两组均经过5周治疗。观察两组的临床疗效,比较治疗前后两组患者WOMAC和Lysholm评分以及血清学指标差异。结果治疗后,对照组的临床总有效率为82.93%,显著低于治疗组患者的97.56%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者WOMAC评分明显降低,Lysholm评分明显升高,同组比较差异具有统计学意义(P<0.05);且治疗组患者WOMAC和Lysholm评分比对照组改善更显著,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、环氧化酶-2(COX-2)、基质金属蛋白酶-12(MMP-12)水平均显著降低,同组比较差异具有统计学意义(P<0.05);且治疗组患者上述血清学指标水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论痹祺胶囊联合玻璃酸钠治疗膝骨性关节炎可有效改善患者膝关节功能,降低机体炎症反应,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Biqi Capsules combined with sodium hyaluronate in treatment of knee osteoarthritis. Methods Patients（82 cases） with knee osteoarthritis in Weinan Central Hospital from February 2016 to February 2017 were divided into control（41 cases） and treatment（41 cases） groups according to the different treatments. Patients in the control group were intraarticular injection administered with Sodium Hyaluronate Injection, 2 mL/time, once weekly. Patients in the treatment group were po administered with Biqi Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 5 weeks. After treatment, the clinical efficacy was evaluated, the difference of WOMAC and Lysholm scores, and serum markers in two groups before and after treatment was compared. Results After treatment, clinical efficacy in the control group was 82.93%, which were significantly lower than 97.56% in the treatment group, and there were differences between two groups（P〈0.05）. After treatment, the WOMAC score in two groups was significantly decreased, but the Lysholm score was significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the improvement of WOMAC and Lysholm score in the treatment group was more significant than that in the control group, with significant difference between two groups（P〈0.05）. After treatment, the IL-6, TNF-α, COX-2, and MMP-12 levels in two groups were significantly decreased, there were differences in the same group（P〈0.05）. And these serum markers levels in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Biqi Capsules combined with sodium hyaluronate can effectively improve the knee function and reduce the inflammatory reaction in treatment of knee osteoarthritis, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2017年第12期2438-2441,共4页
Drugs & Clinic
