摘要
目的探讨喉鳞状细胞癌患者血清细胞质胸苷激酶1(S-TK1)的表达水平及临床意义。方法选取223例喉鳞状细胞癌患者为试验组,采集患者术前、术后1周、术后1个月空腹血液样本各1份;另选取280例健康体检者为对照组,采集血液样本。检测所有血液样本的S-TK1浓度,比较两组研究对象的S-TK1浓度及阳性率。结果术前试验组患者的S-TK1浓度为(3.06±0.16)pmol/L,高于对照组的(1.28±0.75)pmol/L,差异有统计学意义(P﹤0.05);术前试验组患者的S-TK1阳性率为50.22%(112/223),明显高于对照组的13.57%(38/280),差异有统计学意义(P﹤0.01)。Ⅰ、Ⅱ、Ⅲ、Ⅳ期喉鳞状细胞癌患者的S-TK1浓度及阳性率比较,差异均无统计学意义(P﹥0.05);Ⅰ+Ⅱ期与Ⅲ+Ⅳ期喉鳞状细胞癌患者的S-TK1浓度及阳性率比较,差异均无统计学意义(P﹥0.05)。中分化、低分化喉鳞状细胞癌患者的S-TK1阳性率均高于高分化患者,差异有统计学意义(P﹤0.05);高分化、中分化喉鳞状细胞癌患者的S-TK1浓度均低于低分化患者,差异有统计学意义(P﹤0.05)。术前喉鳞状细胞癌患者的S-TK1阳性率和S-TK1浓度与术后1周比较,差异均无统计学意义(P﹥0.05);术后1个月喉鳞状细胞癌患者的S-TK1阳性率和浓度均低于术前,差异有统计学意义(P﹤0.05)。结论 S-TK1浓度可以作为喉鳞状细胞癌诊断与术后评估的指标之一,其表达水平与喉鳞状细胞癌的组织学分级有关,可通过其浓度分析喉鳞状细胞癌的恶性程度。
Objective To investigate the expression and clinical significance of serum thymidine kinase 1（S-TK1）.Method 223 patients with laryngeal squamous cell carcinoma were included as study group, of which the fasting blood samples before surgery, 1 week after surgery, and 1 month after surgery were collected, respectively, and another 280 cases of normal subjects were enrolled as control group, with blood samples collected. All blood samples were determined for S-TK1 concentration, and the positive rates were compared between the two groups. Result The concentration of S-TK1 in study group befor surgery was（3.06±0.16） pmol/L, higher than the（1.28±0.75） pmol/L in control group, the difference was statistically significant（P〈0.05）; the positive rate of S-TK1 in study group before surgery was 50.22%（112/223）,which was significantly higher compared with control group at 13.57%（38/280）, with significant difference observed（P〈0.01）. As for the S-TK1 concentration and positive rates among patients with stage I, II, III and IV disease, similar results were observed（P〈0.05）; same findings were noted for subgroups of I ＋ II stage vs III ＋ IV stage（P〈0.05）. Patients with moderately or poorly differentiated disease had higher positive rate of S-TK1 as compared with those with highly differentiated disease, and significant difference was observed（P〈0.05）; while patients with highly and moderately differentiated disease were lower in S-TK1 concentration as compared with those with poorly differentiated disease（P〈0.05）. The two measures before and 1 week after surgery in laryngeal squamous cell carcinoma showed no significant variations（P〈0.05）; while 1 month after surgery, both the concentration and positive rate of S-TK1 were decreased compared with before surgery, and the difference was of statistically significance（P〈0.05）. Conclusion The concentration of S-TK1 can be used as one of the indicators for diagnosis and postoperative evaluation of laryngeal carc
出处
《癌症进展》
2017年第11期1299-1301,共3页
Oncology Progress
