摘要
目的分析人乳头瘤病毒在女性感染者中的分布特征,评估HPV-DNA分型检测用于筛查宫颈癌的临床价值。方法选择行宫颈癌筛查的患者2560例。采集患者宫颈细胞进行HPV-DNA检测,对HPV-DNA高危型阳性患者行液基细胞学(TCT)检测,TCT阳性者行阴道镜取活检病理检测。结果 2560例妇女中共检测出HPV-DNA阳性者711例(27.8%),其中高危型265例(10.4%),低危型446例(17.4%)。不同分级宫颈病变中HPV类型感染分布差异有统计学意义(P<0.05)。HPV-DNA高危型感染以30岁以下和50岁以上的人群感染率较高,各年龄段患者HPV-DNA高危型感染率差异无统计学意义(χ~2=5.673,P=0.339)。HPV-DNA高危型感染者中病理诊断为宫颈癌患者10例(3.8%),低危型感染者中病理诊断为宫颈癌者2例(0.4%),二者差异有统计学意义(P<0.05)。TCT联合HPV-DNA分型检测的敏感度高于二者单独检测,特异度和假阳性率低于HPV-DNA分型检测,假阴性率低于二者单独检测,差异均有统计学意义(P<0.05)。结论高危型HPV检测用于筛查宫颈癌敏感性和特异性高,可作为辅助宫颈细胞学检测的手段,临床应用价值较高。
Objective To analyze the distribution characteristics of the high-risk human papillomavirus in infected women and evaluate the clinical value of HPV-DNA typing in screening of cervical cancer. Methods Selected 2560 cases of cer- vical cancer screening. Collected the cervical cells for HPV-DNA detection, then the positive of high risk HPV-DNA were given TCT detect,and the positive TCT were given biopsy pathlolgical test. Results There were 711 cases of HPV-DNA positive in 2560 women （27.8%） ,in which 265 were high-risk type （ 10.4% ） ,and 446 patients （ 17.4% ） had low risk. There weresignif- icant differences in the distribution of HPV types in different grades of cervical lesions （ P 〈 0.05 ）. The risk of HPV-DNA infec- tion was high in patients less than 30 and over 50 , no significant difference was found in all ages in patients with high risk HPV- DNA infection （ X2 = 5. 673,P = 0. 339）. There were 10 cases （ 3.8 % ） of cervical cancer with high risk of HPV-DNA infection and 2 cases （ 0.4% ） with low risk of HPV-DNA infection, the difference was statistically significant （ P 〈 0.05 ）. TCT and HPV- DNA test was more sensitive than the 2 individual test, specificity and false positive rate was lower than the HPV-DNA type of de- tection, the false negative rate of less than 2 test alone, the differences were statistically significant （ P 〈 0.05 ）＇. Conclusion High risk HPV test in screening cervical cancer sensitivity and specificity,it can be used as a tool for cervical cytology, and has a high clinical application value.
出处
《实用癌症杂志》
2018年第1期159-162,共4页
The Practical Journal of Cancer
关键词
宫颈癌
人乳头瘤病毒
高危型
筛查
Cervical cancer
Human papillomavirus
High risk type
Screening
