摘要
目的观察及研究膀胱癌术后医院感染患者细胞因子与急性时相反应蛋白的变化情况。方法选取行手术治疗且发生术后医院感染的48例膀胱癌患者为A组,选取同时期的未发生医院感染的48例膀胱癌术后患者为B组,同时期的48例健康人员为C组,然后将三组的血清细胞因子及急性时相反应蛋白水平进行比较,并比较A组中不同感染程度患者的上述血清指标检测结果。结果 A组的血清IL-2水平均低于B组及C组,B组低于C组,其他血清细胞因子与急性时相反应蛋白水平高于B组及C组,B组高于C组,且A组中重度感染患者高于轻度及中度感染患者,中度感染患者则高于轻度感染患者,P均<0.05,均有显著性差异。结论膀胱癌术后医院感染患者细胞因子与急性时相反应蛋白均呈现高表达状态,且不同感染程度患者的表达水平也存在明显差异。
Objective To observe and study the change situation of cytokines and acute phase reaction proteins of pa- tients with nosocomial infection after bladder cancer operation. Methods 48 patients with postoperative nosocomial infection who were treated with operation were selected as group A,48 patients without nosocomial infection after the operation at the same time were selected as group B,48 healthy personnel at the same time were selected as group C, then the serum cytokines and acute phase reaction proteins of 3 groups were compared, and the detection results of those serum indexes of group A with different in- fection degree were compared. Results The serum IL-2 of group A were both lower than those of group B and group C,the serum level of group B was lower than that of group C, other serum cytokines and acute phase reaction proteins were all higher than those of group B and group C, the levels of group B were higher than those of group C, the levels of group A with severe infection were higher than those of patients with mild and moderate infection, the levels of patients with moderate infection were all higher than those of patients with mild infection, all P 〈 0. 05, the differences were all significant. Conclusion The cytokines and acute phase reaction proteins of patients with nosocomial infection after bladder cancer operation show higher expression state, and the expres- sion levels of patients with different infection degree all show obvious differences.
出处
《实用癌症杂志》
2018年第1期36-38,共3页
The Practical Journal of Cancer
关键词
膀胱癌术后医院感染
细胞因子
急性时相反应蛋白
Nosocomial infection after bladder cancer operation
Cytokines
Acute phase reaction proteins
