摘要
皮肤角质层是药物经皮渗透的主要障碍,尤其是对大分子药物或亲水性药物分子,而微米尺寸的微针可以以微创的方式刺穿皮肤角质层,产生可逆的微孔道,促进药物渗透,进而克服传统药物经皮渗透率低的问题。同时,由于微针插入皮肤的深度有限,不触及皮下痛觉神经,可以避免引起疼痛。聚合物微针不仅具有足够的机械强度刺穿皮肤角质层,而且具有优异的生物相容性、载药量可调节范围大等特点,即使断裂在皮肤内,也不会产生安全问题。聚合物微针的众多优势使其在经皮传递药物方面具有广阔的前景,是当前经皮给药领域的研究热点。本文将从聚合物微针的种类、制备方法、经皮给药应用等方面详细综述聚合物微针的最新研究进展,并对这一领域的未来发展进行展望。
Stratum corneum,the protective barrier of the skin,is the principal obstacle for drugs to pass through the skin,especially macromolecular drugs or hydrophilic drugs.M icron-sized microneedles in transdermal drug delivery system can permeabilize the stratum corneum to promote the penetration of skin-impermeant drugs by creating reversible microchannels in the skin in a minimally invasive manner,which can overcome lowpermeability of traditional transdermal drug delivery system.What＇s more,percutaneous microneedle insertion can cause less or even no pain because it has limited insertion depth without touching nerves in the skin.Polymeric microneedles not only have sufficient strength to puncture the stratum corneum but also exhibit other outstanding performances such as biocompatibility and relatively lager drug loading capacity.It is safe even if polymeric microneedles rupture in the skin.Polymeric microneedles have so many advantages that they have an extensive prospect in transdermal drug delivery system,which has received abroad attention.In this paper,the recent advances of polymeric microneedles are reviewed in detail from the following aspects：microneedle types,manufacturing methods,and applications in transdermal drug delivery system.Challenges and prospects of polymeric microneedles are also discussed.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2017年第12期1518-1525,共8页
Progress in Chemistry
基金
浙江省自然科学基金项目(No.LY18E030001)
国家自然科学基金项目(No.21474087)
国家国际科技合作专项(No.2015DFA51010)资助~~
关键词
聚合物微针
经皮给药
微针制备
polymeric microneedles
transdermal drug delivery
manufacturing of microneedles
