摘要
目的:观察自拟补肾消癥汤源头治疗肾虚血瘀型子宫内膜异位症的临床疗效,以治疗前后在位内膜CD146表达水平及新生血管数目(MVD)为主要观察指标,探讨其作用机制。方法:选取2014年3月—2016年3月山东省聊城市中医医院妇科门诊就诊的肾虚血瘀型子宫内膜异位症患者60例,按照随机区组法分为治疗组和对照组,每组30例。治疗组给予补肾消癥汤治疗,对照组给予调经促孕丸及散结镇痛胶囊治疗,两组疗程均为3个月经周期,随访3个月。观察临床疗效、中医证候疗效、症状积分改善情况,治疗前后在位子宫内膜CD146表达水平及新生血管数目。结果:治疗组有效率93.33%,对照组有效率66.67%,治疗组疗效优于对照组(P<0.05);治疗组治疗后中医证候积分、盆腔包块大小、外周血血清CA125、在位子宫内膜CD146表达阳性率、在位子宫内膜MVD数目均优于对照组(P<0.05或P<0.01)。结论:补肾消癥汤源头治疗肾虚血瘀型子宫内膜异位症疗效确切,其作用机制与改善患者的子宫内膜特性,降低患者在位内膜细胞自身所具备的侵袭、黏附能力及进一步形成新生血管的能力,从而遏制子宫内膜异位病灶的形成及进展有关。
Objective：To observe the clinical effects of Kidney-Tonifying and Mass-Resolving Decoction on endometriosis of syn- drome of kidney deficiency and blood stasis. The expression level of CD146 and MVD are the main observation indicators to ex- plore its mechanism. Methods ：Totally 60 patients with endometriosis of syndrome of kidney deficiency and blood stasis treated in Liaocheng Hospital of Chinese Medicine between March 2014 and March 2016 were randomized into treatment group and control group,30 cases in each group. Treatment group were given Kidney-Tonifying and Mass-Resolving Decoction while control group were given Menstruation-Regulating and Pregnancy-Promoting Pill and Mass-Dispersing and Pain-Checking Capsules for the treat- ment,3 menstrual periods as a treatment course and 3 months of follow up for both groups. The clinical effects, efficacy of TCM syndromes,improvement of the symptom scores, the expression level of CD146 and MVD were observed. Results ：The effective rate was 93.33% in treatment group and 66.67% in control group;treatment group were superior to control group. The TCM symptom scores, size of cervical mass, CA125 in the peripheral serum, positive rate of the expression of CD146 and number of MVD in treatment group were superior to those in control group （ P 〈 0.05 or P 〈 0.01 ）. Conclusion ： Kidney-Tonifying anti Mass-Resol- ving Decoction has definite therapeutic effects on endometfiosis of syndrome of kidney deficiency and blood stasis. The mechanism is associated with the improvement of endometrium feature,reduction of the invasion and adhesion abilityof the endometrial cells as well as the angiogenesis to inhibit the formation of the focus of endometriosis.
出处
《河南中医》
2017年第12期2184-2187,共4页
Henan Traditional Chinese Medicine
关键词
子宫内膜异位症
肾虚血瘀型
补肾消汤
源头治疗
CD146
新生血管数目
endometriosis
syndrome of kidney deficiency and blood stasis
Kidney-Tonifying anti Mass-Resolving Decoction
source treatment
CD146
MVD
