摘要
中枢免疫对于神经系统内稳态的维持意义重大。免疫活性分子TNFα及其受体系统参与神经发育、突触可塑性和认知功能调节;其表达异常,无论过度或者不足都可能导致对脑功能和行为的不良影响。应激,尤其是发育早期应激可能通过影响中枢TNFα的动态发展过程从而造成其功能的持续改变,并与后期免疫相关的心理病理发生密切相关。未来研究需拓展中枢免疫与认知功能障碍之间的因果联系,建立基于免疫调节的疾病防治新策略。
Central immune activities exert important roles in maintaining homeostatic process of central nervous system. It has shown that the dynamically balance of brain TNFα participates in the regulation of neurodevelopment, synaptic plasticity and cognitive function by its receptor signaling, while imbalance of TNFα signaling, no matter excessive or insufficient, can result in adverse effects on brain function and behavior. Stress, especially early stress, may disturb the dynamic development process of TNFα signaling and thus cause lasting alterations of its expression and receptor function, which strongly linked to the increasing incidences of immune-related psychopathological disorders in late life. Future studies are needed to deepen the understanding of causal relationships between central immunity and cognitive dysfunction, and establish new strategies for disease prevention and treatment based on immunoregulation.
出处
《心理科学进展》
CSSCI
CSCD
北大核心
2017年第12期2036-2042,共7页
Advances in Psychological Science
基金
国家自然科学基金(No.81471122 and No.31470988)
中国科学院(KJZD-EW-L04)
中国科学院心理健康重点实验室(中国科学院心理研究所)资助
关键词
内稳态
TNFΑ
应激
突触可塑性
认知功能
homeostasis
Tumor necrosis factor （TNFα）
stress
synaptic plasticity
cognitive function
