摘要
目的 :观察祛瘀通络方治疗人工全膝关节置换术(TKA)后肢体创伤性反应的作用机制及临床疗效。方法 :选取因单纯膝骨性关节炎行初次单侧人工全膝关节置换术患者60例,随机分为治疗组、对照组各30例,对照组骨科护理常规治疗,治疗组在常规治疗的基础上从术后第2天加服祛瘀通络方水煎剂,每日1剂,观察术后第1,3,5,7天患肢肿胀程度,检测术后第1,3,7天C-反应蛋白(CRP)及炎性因子白细胞介素-6(IL-6)的变化。结果:两组术后第3、7天的CRP、IL-6水平对照组高于治疗组,两组比较差异有统计学意义(P<0.05)。结论:祛瘀通络方可以有效调控术后患者血清中的炎性指标CRP与IL-6水平,明显缓解人工全膝关节置换术后肢体创伤性反应,改善术后膝关节的功能,有利于术后康复。
Objective：To observe the mechanism and clinical effects of Quyu Tongluo formular on limb traumatic reaction after artificial total knee arthroplasty（TKA）.Methods：Total 60 patients suffered from simple knee arthritis receiving the first unilateral TKA were randomly divided into the treatment group and control group,30 patients in each,the control group received the routine treatment,Quyu Tongluo formular was administered to the treatment group a dose per day since the second day after operation,based on the routine treatment.The limb swelling degrees of both groups were observed respectively on the 1 st,3 rd,5 th and 7 th day after surgery.The changes of C-reactive protein（CRP） and inflammatory factor interleakin-6（IL-6） on the 1 st,3 rd,and 7 th day after surgery were detected.Results：The levels of CRP and IL-6 in the control group were higher than those in the treatment group on the 3 rd and 7 th day after surgery.There was statistical significance between the two groups（P〈0.05）.Conclusion：Quyu Tongluo formular can effectively regulate the inflammatory indexes CRP and IL-6 in patients after surgery,significantly relieve the limb traumatic reaction after total knee arthroplasty and improve the function of the knee joint and postoperative rehabilitation.
作者
阎伟
李金松
闫茹
刘希斗
骆帝
宋克伟
YAN Wei;LI Jinsong;YAN Ru;LIU Xidou;LUO Di;SONG Kewei(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China;Tengzhou Orthopedics Hospital,Tengzhou 277500, China;Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《山东中医药大学学报》
2017年第6期546-549,共4页
Journal of Shandong University of Traditional Chinese Medicine
基金
山东省中医药科技发展计划项目(编号:2015-085
2009-043)
