摘要
目的探讨白细胞介素23受体(IL-23R)基因单核苷酸多态性与复发性口腔溃疡(ROU)的易感性。方法选取ROU患者42例及年龄、性别匹配的86例正常人,采用应用基质辅助激光解吸附电离飞行时间质谱(MALDI-TOF-MS)技术检测rs11465817和rs1343152基因型。用卡方检验统计两组等位基因和基因型的频率,计算比数比(OR)和95%置信区间(95%CI)评价多态性位点与ROU的遗传易感性。结果 rs1343152位点等位基因和基因型频率在病例组和对照组间差异无统计学意义;rs11465817位点差异显著(OR=2.715,95%CI=1.543~4.777),AA+AC基因型可增加患ROU的易感性2.44倍。结论IL-23R基因rs11465817位点单核苷酸多态性与ROU易感性相关。
Objective To explore whether single nucleotide polymorphism（SNP） in interleukin-23 receptor（IL-23 R）gene is associated with the susceptibility to recurrent oral ulceration（ ROU）. Methods The genotype of SNP rs11465817 and rs1343152 was determined by MALDI-TOF-MS in 42 ROU patients and 86 age-and sex-matched healthy controls. The genotype and allele frequencies were analyzed by Chi-square test in both groups. Odds ratio（ OR） and 95% confidence interval（95%CI） were calculated to analyze the associations between the susceptibility of ROU and the genotypes. Results The rs1343152 allele and genotype frequency distribution had no significantly difference between the case group and the control group. Compared with the control group,rs11465817 allele and genotype frequency distribution in the ROU group had significant difference（ OR = 2. 715,95% CI = 1. 543-4. 777）. The AA ＋ AC genotype increased the risk of ROU occurrence by2. 44 times. Conclusion IL-23 R rs11465817 contributes to the risk of ROU in Chinese.
作者
吴丰苏
汪玉红
刘青
黄萍
孙茂
WU Fengsu;WANG Yuhong;LIU Qing;HUANG Ping;SUN Mao(Cadet Brigade;Department of Mucosa, Hospital of Stomatology;Department of Clinical Laboratory, Hospital of Stomatology, 4Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fourth Military Medical University, Xi ＇an 710032, China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2017年第10期1404-1408,共5页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金面上项目(81671476)
陕西省重点产业创新项目(2016KTZDSF-01-03)
