摘要
目的探讨初诊2型糖尿病(T2DM)患者血清趋化素、网膜素-1水平变化及其与血糖、血脂、胰岛素水平等的关系。方法酶联免疫吸附法(ELISA)检测50例初诊2型糖尿病患者(T2DM组)、50例糖耐量正常者(NGT组)的血清趋化素、网膜素-1水平,同时测定身高、体质量、血糖、血脂、胰岛素水平等,计算体质量指数(BMI)、稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)。结果 T2DM组血清趋化素水平(14±7)ng/ml明显高于NGT组(13±8)ng/ml(P<0.05),网膜素-1水平(230±126)ng/ml明显低于NGT组(368±238)ng/ml(P<0.01)。多元逐步回归分析表明HOMA-IR是影响网膜素-1水平的独立相关因素,趋化素与各代谢指标间均呈相关性,但与网膜素-1存在呈负相关。结论网膜素-1可能参与胰岛素抵抗,在T2DM的发病机制中发挥重要作用。而趋化素可能并未直接参与糖代谢调节。网膜素-1与趋化素之间的具体相互影响机制仍需进一步探索验证。
Objective To investigate the changes of serum chemerin and omentin-1 levels in patients with newly diagnosed type 2 diabetes mellitus（T2DM） and their relationship with blood glucose, lipids and insulin levels.Methods Serum chemerin and omentin-1 levels in 50 newly diagnosed T2DM patients（T2DM group） and 50 individuals with normal glucose tolerance（NGT group） were measured with enzyme-linked immunosorbent assay（ELISA）.Meanwhile, the subjects with measured for height, weight, blood glucose, blood lipids and insulin levels to calculate the body mass index（BMI）, homeostasis model assessment of insulin resistance index（HOMA-IR） and homeostasis model assessment for β cell function index（HOMA-β）. Results The level of chemerin in T2DM group was significantly higher than that in the NGT group [（14±7）ng/ml vs（13±8）ng/ml, P〈0.05], and the level of omentin-1 was significantly lower than that in NGT group [（230±126）ng/ml vs（368±238）ng/ml, P〈0.01]. Multiple stepwise regression analysis showed that HOMA-IR was independently associated with omentin-1 levels. The chemerin level was not significantly correlated with any of the metabolic indice, but was negatively correlated with omentin-1 level. Conclusion Omentin-1 may be involved in insulin resistance and therefore playing an important role in the development of T2DM. Chemerin may not be directly involved in regulating glucose metabolism. The exact interaction between o-mentin-1 and chemerin remains to be further clarified and validated.
出处
《中国药物与临床》
CAS
2017年第12期1728-1730,共3页
Chinese Remedies & Clinics
基金
山西省科技攻关项目(20130313017-9)
