摘要
目的:观察保胎汤配合低剂量地屈孕酮应用于治疗黄体功能不全型先兆流产的临床效果。方法:以2014年6月-2016年6月于本院接受治疗的138例黄体功能不全型先兆流产者为研究对象,随机分为观察组(69例)和对照组(69例)。对照组予以常规剂量地屈孕酮西医治疗,观察组常规剂量地屈孕酮治疗基础上加用保胎汤配合治疗,比较两组治疗后血清孕酮(P)和人绒毛膜促性腺激素(HCG)水平,阴道止血时间、腰酸缓解时间和腹痛缓解时间,记录治疗期间的药物不良反应发生情况,统计患者保胎成功率、新生儿体重和早产情况。结果:治疗后两组患者血清P和HCG水平均显著高于治疗前水平,且观察组高于对照组(P<0.05);观察组阴道止血时间、腹痛缓解时间和腰酸缓解时间均短于对照组,不良反应发生率(4.4%)低于对照组(13.0%),保胎成功率(95.7%)高于对照组(82.6%)(均P<0.05),妊娠不良事件发生率(13.6%)与对照组(14.0%)无差异(P>0.05)。结论:较常规西医孕激素补充治疗,加以保胎汤配合治疗后可显著调节患者激素水平,缩短症状缓解周期,降低治疗期间药物不良反应,提高保胎成功率,值得临床应用。
Objective：To observe the clinical efficacy of Baotai decoction combined with low dose of dydrogesterone for treating pregnant women with threatened abortion caused by luteal phase defect.Methods：138 pregnant women with threatened abortion caused by luteal phase defect in Anji county traditional chinese medicine hospital from June 2014 to June 2016 were randomly divided into two groups,which included study group（n=69）and control group（n=69）.Pregnant women in control group were treated by routine dose of dydrogesterone therapy,and pregnant women in study group were treated by Baotai decoction combined with low dose dydrogesterone.The level of serum progesterone（P）and human chorionic gonadotropin（HCG）of pregnant women were compared between the two groups after treatment.The time of bleeding stop,and time of abdominal and backache pain remission of included women were compared between the two groups.The rate of adverse effects of drugs were recorded during treatment.The success rate of tocolytic theraphy,birth weight of newborn,and rate of preterm birth were also analyzed.Results：The level of serum P and HCG of women in study group were significantly higher than those of women in control group（P〈0.05）.The time of vaginal bleeding stop,and time of abdominal and backache pain remission of women in study group were significantly shorter than those of women in control group.The incidence of side effect of women（4.4%）in study group was significant lower than that of women（13.0%）in control group（P〈0.05）,and the success rate of tocolytic theraphy of women（95.7%）in study group was significantly higher than that of women（82.6%）in control group（P〈0.05）.The rate of adverse events of women（13.6%）in study group had no significant difference when compared to that of women（14.0%）in control group（P〉0.05）.Conclusion：Compared to the conventional western medicine progesterone therapy,Baotai Decoction combined with low dose of progesterone can significantly modulate
作者
戴晓菊
DAI Xiaoju(Anji County Traditional Chinese Medicine Hospital of Zhejiang Province, 313300)
出处
《中国计划生育学杂志》
2017年第12期851-854,共4页
Chinese Journal of Family Planning
关键词
先兆流产
保胎汤
低剂量地屈孕酮
不良反应
妊娠结局
Threatened abortion
Baotai deeoction
Low dose of dydrogesterone
Adverse reactions
Pregnancy out-come
