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Systemic Therapy after Radiotherapy Significantly Reduces the Risk of Mortality of Patients with 1-3 Brain Metastases: A Retrospective Study of 250 Patients 被引量:2

Systemic Therapy after Radiotherapy Significantly Reduces the Risk of Mortality of Patients with 1-3 Brain Metastases: A Retrospective Study of 250 Patients
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摘要 Background:For patients with a brain metastasis (BM),systemic therapy is usually administered after the completion of radiotherapy,especially in cases of multiple BMs.However,the role of systemic therapy in patients with a limited number of BMs is not clear.Therefore,we conducted a retrospective study to explore this question.Methods:Consecutive patients with a pathologically confirmed malignancy and 1-3 intracranial lesions that had been documented within the last decade were selected from the databases of three hospitals in China.Results:A total of 250 patients were enrolled;of them,135 received radiotherapy alone and 115 received radiotherapy plus systemic therapy.In patients receiving whole-brain radiation therapy (WBRT) as radiotherapy,28 received WBRT alone and 35 patients received WBRT plus systemic therapy.Of the patients treated with stereotactic radiosurgery (SRS),107 received SRS alone and 80 received SRS plus systemic therapy.Multivariate analysis revealed that systemic therapy significantly reduced the risk of mortality compared with radiotherapy alone (hazard ratio [HR] =0.294,95% confidence interval [CI] =0.158-0.548).Further,when the analysis was conducted in subgroups ofWBRT (HR =0.230,95% CI =0.081-0.653) or SRS (HR=0.305,95% CI=0.127-0.731),systemic therapy still showed the ability to reduce the risk of mortality in patients with BMs.Conclusion:Systemic therapy after either SRS or WBRT radiotherapy may significantly reduce the risk of mortality of patients with 1-3 BMs. Background:For patients with a brain metastasis (BM),systemic therapy is usually administered after the completion of radiotherapy,especially in cases of multiple BMs.However,the role of systemic therapy in patients with a limited number of BMs is not clear.Therefore,we conducted a retrospective study to explore this question.Methods:Consecutive patients with a pathologically confirmed malignancy and 1-3 intracranial lesions that had been documented within the last decade were selected from the databases of three hospitals in China.Results:A total of 250 patients were enrolled;of them,135 received radiotherapy alone and 115 received radiotherapy plus systemic therapy.In patients receiving whole-brain radiation therapy (WBRT) as radiotherapy,28 received WBRT alone and 35 patients received WBRT plus systemic therapy.Of the patients treated with stereotactic radiosurgery (SRS),107 received SRS alone and 80 received SRS plus systemic therapy.Multivariate analysis revealed that systemic therapy significantly reduced the risk of mortality compared with radiotherapy alone (hazard ratio [HR] =0.294,95% confidence interval [CI] =0.158-0.548).Further,when the analysis was conducted in subgroups ofWBRT (HR =0.230,95% CI =0.081-0.653) or SRS (HR=0.305,95% CI=0.127-0.731),systemic therapy still showed the ability to reduce the risk of mortality in patients with BMs.Conclusion:Systemic therapy after either SRS or WBRT radiotherapy may significantly reduce the risk of mortality of patients with 1-3 BMs.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第24期2916-2921,共6页 中华医学杂志(英文版)
关键词 Brain Metastasis Stereotactic Radiosurgery Systemic Therapy Whole-brain Radiation Therapy Brain Metastasis Stereotactic Radiosurgery Systemic Therapy Whole-brain Radiation Therapy
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