摘要
心肌肥厚是心脏在应激情况下的代偿反应,生理性心肌肥厚可以提高心脏的生理功能,但病理性的心肌肥厚会对心脏造成一系列不利的影响,如发生心律失常、心衰及猝死等危险。最近多项研究发现,A型激酶锚定蛋白(AKAPs)协同多种信号因子参与病理性心肌肥厚的调节过程,本文就AKAPs对病理性心肌肥厚的调控机制及临床意义作一综述。
Cardiac hypertrophy is the compensatory response of the heart in response to stimulation.Cardiac hypertrophy can improve the physiological function of the heart,but pathological myocardiac hypertrophy can cause a series of adverse effects on the heart such as arrhythmia,heart failure and sudden death risk.Recent studies revealed that AKAPs participates in the regulation of pathological myocardiac hypertrophy with multiple signal factors.Here we review the role of the A-kinase anchoring protein （AKAPs） in the regulation of pathological hypertrophy and its clinical significance.
作者
王政
汪和贵
WANG Zheng;WANG Hegui(Department of Cardiology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241000 ,Anhui, China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2017年第11期1304-1308,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
安徽省高校自然科学研究重大项目(KJ2015ZD42)
皖南医学院弋矶山医院引进人才项目(YR201615)
