摘要
目的通过文献评价探讨慢性牙周炎与趋化因子白细胞介素-8(IL-8)的关系。方法计算机检索中国期刊全文数据库(CNKI)、万方数据库、Pub Med检索平台和Embase数据库,收集国内外发表的关于慢性牙周炎IL-8水平的研究性论文。检索时间均从建库至2016年,按纳入和排除标准筛选文献,应用Stata12.0软件进行Meta分析。结果慢性牙周炎患者龈沟液中IL-8水平明显高于正常对照组(P<0.05)。Meta分析结果显示,亚洲人群慢性牙周炎患者龈沟液中IL-8水平高于正常对照组(P<0.05),而西方人群两者差异无统计学意义(P>0.05)。结论亚洲人群慢性牙周炎患者和正常对照组之间IL-8有显著差异,IL-8可能会增加慢性牙周炎的风险。
Objective To explore the relationship between chronic periodontitis and cytokine interleukin-8 （IL-8） by literature review.Methods The CNKI,Wanfang database,PubMed retrieval platform and Embase database were searched by computer.The research papers on the level of interleukin-8 in chronic periodontitis were collected.The retrieval time was up to 2016;screen literature according to the inclusion and exclusion criteria;use Stata12.0 software for meta analysis.Results The level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was significantly higher than that in normal controls （P 〈 0.05）.In the Asian population,the level of IL-8 in gingival crevicular fluid in patients with chronic periodontitis was higher than that in normal controls （P 〈 0.05）.In the western population,there was no difference in the level of IL-8 in gingival crevicular fluid between patients with chronic periodontitis and normal controls（P 〉 0.05）.Conclusion There is a significant difference in chemokines interleukin-8 between patients with chronic periodontitis and normal controls in the Asian population.Chemokines interleukin-8 may increase the risk of chronic periodontitis.
作者
冯萍珍
保森竹
FENG Ping-zhen;BAO Sen-zhu(Affiliated Hospital of Qinghai University , Xining 810001, China)
出处
《中国实用口腔科杂志》
CAS
2017年第11期687-691,共5页
Chinese Journal of Practical Stomatology
关键词
趋化因子
牙周炎
牙龈沟液
chemokines
periodontitis
gingival crevicular fluid
