摘要
一磷酸腺苷激活的蛋白激酶(AMPK)广泛存在于真核细胞中,AMPK的活性受一磷酸腺苷(AMP)/三磷酸腺苷(ATP)的调节,应激反应可通过ATP的产生减少或消耗使细胞内AM P/ATP增加,从而激活AMPK。激活的AMPK可通过磷酸化下游靶蛋白,改变脂类和碳水化合物代谢,使其朝着抑制ATP消耗过程、促进ATP生成反应的方向进行,即抑制脂肪酸和糖原合成,促进脂肪酸氧化分解和葡萄糖的吸收,从而迅速恢复细胞中的能量,因此AMPK被称为"细胞能量调节器",在动物适应环境的过程中发挥着重要的作用。本文在国内外已有文献报道基础上,对AMPK的结构、分布、活性调节及对糖脂代谢的调节作用进行综述。
The adenosine monophosphate-activated protein kinase （AMPK） is found in all eukaryotic cells. AMPK activity is a response to adenosine monophosphate （AMP）/adenosine triphosphate （ATP）. When a stress causes an inhibition of ATP production or an increase of ATP consumption, cellular AMP/ATP increa- ses, AMPK is activated. Once activated AMPK can phosphorylates its downstream target proteins. As a result, the lipid and carbohydrate metabolisms are changed towards the switches on promoting ATP-producing and in- hibiting ATP-consumption pathways, such as inhibitions of fatty acid and glycogen synthesis, stimulations of fatty acid oxidation and glucose absorption, by which energy in cells are rapidly recovered. Thus AMPK is called regulator of cell energy, and plays an important role for animals to adapt to the environment. This review summarized the structure, distribution, activity regulation and the regulatory roles on the glucose and lipid me- tabolism of AMPK based on the previous studies at home and abroad.
作者
高晓娜
郭小权
GAO Xiaona;GUO Xiaoquan(College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, Chin)
出处
《动物营养学报》
CAS
CSCD
北大核心
2017年第12期4287-4294,共8页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金(31460679)
江西省自然科学基金重点项目(2017ACB20012)
