摘要
目的:探讨静吸复合麻醉对老年股骨颈骨折患者术中血流动力学稳态及术后脑功能、Th1/Th2免疫的影响。方法:2016年7月~2017年6月间在本院接受髋关节置换术治疗的老年股骨颈骨折患者176例,回顾麻醉方案并将入组患者分为全凭静脉麻醉组86例、静吸复合麻醉组90例。对比两组术中血流动力学参数水平,术后脑功能指标、Th1/Th2细胞因子含量的差异。结果:术中,静吸复合麻醉组血流动力学参数MAP、HR的水平低于全凭静脉麻醉组。术后24h,静吸复合麻醉组血清中脑功能指标MBP、S100B、NSE的含量低于全凭静脉麻醉组;血清中Th1细胞因子IFN-γ、IL-2的含量高于全凭静脉麻醉组,Th2细胞因子IL-4、IL-13的含量低于全凭静脉麻醉组。结论:老年股骨颈骨折患者采用静吸复合麻醉,可有效稳定术中血流动力学并减少术后脑功能、Th1/Th2免疫功能损伤。
Objective:To explore the effects of intravenous inhalational anesthesia on the hemodynamic homeostasis as well as postoperative brain function and Th1/Th2 immunity in elderly patients with femoral neck fracture.Methods:176 elderly patients with femoral neck fracture who received hip replacement in our hospital between July 2016 and June 2017 were divided into the total intravenous anesthesia group(n=86)and the intravenous inhalational anesthesia group(n=90)according to the anesthesia solution.The differences in introperative hemodynamic parameter levels as well as postoperative brain function index and Th1/Th2 cytokine contents were compared between the two groups.Results:During operation,hemodynamic parameters MAP and HR levels in intravenous inhalational anesthesia group were lower than those in total intravenous anesthesia group.24 hafter operation,serum brain function indexes MBP,S100 Band NSE contents in intravenous inhalational anesthesia group were lower than those in total intravenous anesthesia group;serum Th1 cytokines IFN-γand IL-2 contents were higher than those in total intravenous anaesthesia group whereas Th2 cytokines IL-4 and IL-13 contents were lower than those in total intravenous anesthesia group.Conclusion:The intravenous inhalational anesthesia can effectively stabilize the intraoperative hemodynamics and reduce the postoperative brain function and Th1/Th2 immune function injury in elderly patients with femoral neck fracture.
出处
《海南医学院学报》
CAS
2017年第23期3234-3238,共5页
Journal of Hainan Medical University
基金
四川省崇州市科技局项目(s201631)~~
