摘要
目的:研究罗哌卡因联合舒芬太尼与罗哌卡因单药用于硬膜外分娩镇痛的效果。方法:选择在本院进行硬膜外镇痛下经阴道分娩的初产妇,随机分为接受罗哌卡因联合舒芬太尼硬膜外镇痛的A组以及接受罗哌卡因单药硬膜外镇痛的B组。第一产程、第二产程、第三产程中,采集血清并测定疼痛介质SP、5-HT、PGE2及应激激素NE、E、F-C、AT-II、INS的含量;分娩后,采集胎盘组织并测定应激分子GRP78、CHOP、Nrf-2、ARE的表达量。结果:A组产妇第一产程、第二产程、第三产程血清中SP、5-HT、PGE2、NE、E、F-C、AT-II、INS的含量均显著低于B组;A组产妇分娩后胎盘组织中GRP78、CHOP、Nrf-2、ARE的mRNA表达量均显著低于B组。结论:罗哌卡因联合舒芬太尼用于硬膜外分娩镇痛能够较罗哌卡因单药更为有效的减轻疼痛并抑制应激反应。
Objective：To study the efficacy of ropivacaine combined with sufentanil and ropivacaine alone for epidural labor analgesia.Methods：Primiparae who received vaginal delivery under epidural analgesia in Ankang People＇s Hospital between March 2015 and February 2017 were selected and randomly divided into accepting the group A who received ropivacaine combined with sufentanil for epidural analgesia and the group B who received ropivacaine alone for epidural analgesia.During the first,the second and the third stage of labor,the serum was collected to determine the levels of pain mediators SP,5-HT and PGE2 as well as stress hormones NE,E,F-C,AT-II and INS;after delivery,the placenta tissue was collected to determine the expression of stress molecules GRP78,CHOP,Nrf-2 and ARE.Results：Serum SP,5-HT,PGE2,NE,E,F-C,AT-II and INS levels of group A during the first,the second and the third stage of labor were significantly lower than those of group B;GRP78,CHOP,Nrf-2 and ARE mRNA expression in placental tissue of group A after delivery were significantly lower than those of group B.Conclusion：ropivacaine combined with sufentanil for epidural labor analgesia is more effective than ropivacaine alone in reducing pain and inhibiting stress response.
出处
《海南医学院学报》
CAS
2017年第20期2801-2803,2807,共4页
Journal of Hainan Medical University
基金
安康市二〇一六年科学技术研究发展计划(2016AK-03-12)~~
