摘要
抗磷脂抗体是一组可以与细胞表面上带负电荷的磷脂特异性结合的抗体,主要包括抗心磷脂抗体、狼疮凝固抑制物以及抗β2糖蛋白Ⅰ抗体。它们可引起一系列特征性临床症状,统称为抗磷脂综合征(APS),目前国际上对此已有较为一致的分类诊断标准。大量研究表明,抗心磷脂抗体与不孕、流产、死胎、子痫前期、胎盘功能不全等不良妊娠结局有关,但其具体致病机制尚未完全明确。但是也有研究者认为,抗心磷脂抗体并非引起不良妊娠结局的主要原因。综述抗心磷脂抗体与不良妊娠结局的相关性,以期今后的研究能够进一步优化实验设计,明确分类诊断标准,获得更权威可信的研究结果,更好地指导临床实践。
Antiphospholipid antibodies are a group of antibodies with specificity for binding to negatively charged phospholipids on the cell surface, including anticardiolipin antibodies, lupus coagulation inhibitor and anti-beta 2-glycoprotein Ⅰ antibodies. They can cause a series of characteristic clinical symptoms, which are referred to as antiphospholipid syndrome.There is an international consensus on the classification criteria for definite antiphospholipid syndrome. Numerous studies have shown that anticardiolipin antibodies are associated with several adverse pregnancy outcomes, such as infertility, abortion,stillbirth, preeclampsia, placental insufficiency and so on. But its pathogenic mechanism is not yet clear. However, some investigators believe that anticardiolipin antibodies are not the main cause of adverse pregnancy outcomes. This paper focuses on the association between anticardiolipin antibodies and adverse pregnancy outcomes. And it also suggests investigators to optimize the experimental design and diagnostic criteria for classification, hopes to obtain more authoritative results using to guide clinical practice.
出处
《国际妇产科学杂志》
CAS
2017年第6期618-621,共4页
Journal of International Obstetrics and Gynecology
关键词
抗体
抗心磷脂
抗体
抗磷脂
狼疮凝固抑制物
β2糖蛋白Ⅰ
抗磷脂综合征
妊娠结局
Antibodies
anticardiolipin
Antibodies
antiphospholipid
Lupus coagulation Inhibitor
Beta 2-glycoprotein Ⅰ
Antiphospholipid syndrome
Pregnancy outcome
