摘要
目的探讨伴随肺纤维化的髓过氧化物酶(MPO)阳性抗中性粒细胞胞浆抗体(ANCA)相关性血管炎患者临床特征及实验室指标间的相关性。方法将33例MPO阳性ANCA相关性血管炎患者分为伴肺纤维化改变的A组和不伴肺纤维化改变的B组,并以14例结缔组织病相关肺间质纤维化患者作为疾病对照组,12例健康体检者作为健康对照组。分析上述患者的临床资料及实验室指标。结果 B组患者血肌酐水平与疾病对照组及健康对照组相比均显著升高,A组患者血肌酐水平与疾病对照组及健康对照组相比具有一定程度升高,但差异无统计学意义;A组、B组以及疾病对照组患者血纤维蛋白原(FIB)、D二聚体(D-D)、超敏C反应蛋白(hsCRP)的水平均较健康对照组显著升高(均P<0.05),且在A组中,MPO的表达水平与FIB值呈正相关(r=0.64,P<0.05)。结论在肺纤维化疾病中,早期监测ANCA对于ANCA相关性血管炎的诊断具有一定临床价值,且ANCA靶抗原MPO水平在反映血栓形成风险中具有一定临床意义。
Objective To explore the clinical features of antineutrophil cytoplasmic antibodies-associated vasculitis combined with pulmonary fibrosis and the relationship of laboratory results.Methods Totally,33 patients with antineutrophil cytoplasmic antibodies-associated vasculitis were divided into pulmonary fibrosis group(group A)and non-pulmonary fibrosis group(group B).Fourteen patients with connective tissue diseases-related pulmonary fibrosis served as disease control group,and 12 healthy people as normal control group.The levels of ANCA,plasma creatinine,high-sensitivity C-reactive protein,fibrinogen and D-dimer were detected.Results The creatinine level was significantly higher in group B than in disease control group and normal control group.The creatinine level was higher in group A than in disease control group and normal control group,without significant differences.The levels of FIB,D-D,and hsCRP were significantly higher in the group A,group B and disease control group(all P<0.05).In the group A,MPO expression was positively associated with FIB concentration(r=0.64,P<0.05).Conclusion In pulmonary fibrosis disease,early detection of ANCA has clinical value in the diagnosis of AASV.And the higher concentration of MPO may hint thrombus formation.
出处
《华中科技大学学报(医学版)》
CAS
CSCD
北大核心
2017年第6期680-682,691,共4页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
武汉市卫生计生委科研基金资助项目(No.WX16D32)