α-硫辛酸联合神经生长因子对股骨骨折术后骨代谢、氧化应激、神经传导功能的影响被引量：4

Effect ofα-lipoic acid combined with nerve growth factor on bone metabolism,oxidative stress and nerve conduction function after femoral fracture surgery

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摘要目的:探讨α-硫辛酸联合神经生长因子对股骨骨折术后骨代谢、氧化应激、神经传导功能的影响。方法:收集2015年1月~2017年1月间在本院接受手术治疗的股骨骨折患者110例,经随机数表法分为对照组、研究组患者各55例。对照组患者术后接受神经生长因子治疗,研究组患者术后接受α-硫辛酸联合神经生长因子治疗。对比两组治疗前后骨代谢、氧化应激指标含量,神经传导功能指标水平的差异。结果:治疗前,两组患者骨代谢、氧化应激指标含量,神经传导功能指标水平的差异无统计学意义。治疗后,研究组血清中骨代谢指标BGP、PⅠNP的含量高于对照组,CTX-Ⅰ、TRAP的含量低于对照组;研究组血清中氧化应激指标TAC、CAT、SOD的含量高于对照组,MDA的含量低于对照组;研究组患肢神经传导速度SCV、MCV的水平高于对照组。结论:股骨骨折术后接受α-硫辛酸联合神经生长因子治疗,可有效平衡成骨/破骨细胞活性,降低机体氧化应激反应,提升患肢神经传导速度。 Objective:To discuss the effect ofα-lipoic acid combined with nerve growth factor on bone metabolism,oxidative stress and nerve conduction function after femoral fracture surgery.Methods:110 patients with femoral fracture who received surgical treatment in the hospital between January 2015 and January 2017 were collected and divided into the control group(n=55)and study group(n=55)by random number table.Control group received postoperative nerve growth factor therapy,and study group received postoperativeα-lipoic acid combined with nerve growth factor therapy.The differences in the contents of bone metabolism and oxidative stress indexes as well as the levels of nerve conduction function indexes were compared between the two groups before and after treatment.Results:Before treatment,the differences in the contents of bone metabolism and oxidative stress indexes as well as the levels of nerve conduction function indexes were not statistically significant between the two groups.After treatment,serum bone metabolism indexes BGP and PⅠNP contents of study group were higher than those of control group while CTX-Ⅰ and TRAP contents were lower than those of control group;serum oxidative stress indexes TAC,CAT and SOD contents of study group were higher than those of control group while MDA content was lower than that of control group;limb nerve conduction velocity SCV and MCV levels of study group were higher than those of control group.Conclusion:α-lipoic acid combined with nerve growth factor therapy after femoral fracture surgery can effectively balance osteoblast/osteoclast activity,reduce oxidative stress and improve limb nerve conduction velocity.

作者曹安军杨建惠牟朋林王俊

机构地区广东省广东药科大学附属第二医院广州新海医院外一科

出处《海南医学院学报》 CAS 2017年第21期2964-2967,共4页 Journal of Hainan Medical University

基金广东省科技计划项目(2012B031200146)~~

关键词股骨骨折 Α-硫辛酸骨代谢氧化应激神经传导 femoral fracture α-lipoic acid bone metabolism oxidative stress nerve conduction

分类号 R683 [医药卫生—骨科学]