摘要
目的:研究胃癌患者抑郁情绪对幽门螺杆菌感染的影响及其与癌基因表达的相关性。方法:选择2015年3月~2017年2月期间在自贡市第三人民医院接受胃癌根治术的82例患者作为研究对象并根据术前HAMD评分分为抑郁组和非抑郁组,测定胃癌病灶内幽门螺旋杆菌感染情况以及增殖基因、侵袭基因的mRNA表达量。结果:抑郁组患者胃癌病灶内幽门螺旋杆菌阳性率显著高于非抑郁组;抑郁组胃癌病灶内LOXL2、RAB1A、UHRF1、Slug、ADAM8的mRNA表达量显著高于非抑郁组,MTS1、NOX、E-cadherin、TIMP1的mRNA表达量显著低于非抑郁组;幽门螺旋杆菌阳性的抑郁组胃癌病灶内LOXL2、RAB1A、UHRF1、Slug、ADAM8的mRNA表达量显著高于幽门螺旋杆菌阴性的抑郁组胃癌病灶,MTS1、NOX、E-cadherin、TIMP1的mRNA表达量显著低于幽门螺旋杆菌阴性的抑郁组胃癌病灶。结论:抑郁情绪能够增加胃癌病灶内幽门螺旋杆菌的感染率并促进癌细胞的增殖、侵袭。
Objective:To study the effect of depression on helicobacter pylori infection in patients with gastric cancer and its correlation with oncogene expression.Methods:82 patients who accepted radical operation for gastric cancer in Zigong Third People's Hospital between March 2015 and February 2017 were selected as the research subjects and divided into depression group and non-depression group according to the preoperative HAMD scores,and helicobacter pylori infection as well as the mRNA expression of proliferation genes and invasion genes in gastric cancer lesions was detected.Results:The positive rate of helicobacter pylori in gastric cancer lesions of depression group was significantly higher than that of non-depression group;LOXL2,RAB1 A,UHRF1,Slug and ADAM8 mRNA expression in gastric cancer lesions of depression group were significantly higher than those of non-depression group while MTS1,NOX,E-cadherin and TIMP1 mRNA expression were significantly lower than those of non-depression group;LOXL2,RAB1 A,UHRF1,Slug and ADAM8 mRNA expression in H.pylori-positive gastric cancer lesions of depression group were significantly higher than those in H.pylori-negative gastric cancer lesions of depression group while MTS1,NOX,E-cadherin and TIMP1 mRNA expression were significantly lower than those in H.pylori-negative gastric cancer lesions of depression group.Conclusion:Depression can increase the helicobacter pylori infection rate and promote the proliferation and invasion of cancer cells in gastric cancer lesions.
出处
《海南医学院学报》
CAS
2017年第22期3120-3123,共4页
Journal of Hainan Medical University
基金
自贡市科技局课题项目(J20150169)~~
关键词
胃癌
抑郁
幽门螺旋杆菌
增殖
侵袭
Gastric cancer
Depression
Helicobacter pylori
Proliferation
Invasion
