摘要
神经信号传递始于神经递质从突触囊泡的释放。在此过程中,突触囊泡需要经历释放-回收的动态过程以维持突触前终末的结构和功能完整性。囊泡回收是整个突触囊泡循环的基础。研究表明,网格蛋白介导的内吞作用是囊泡回收的主要途径,发动蛋白(Dynamin)在此过程中发挥重要作用。Dynamin是一个分子质量约为100 k D的GTP酶,其在网格蛋白介导的内吞过程中发挥"剪刀"的作用,将网格蛋白包被小窝与质膜分离。本文将对突触囊泡回收模式、Dynamin作用机制及调控Dynamin后内吞作用的变化3个方面相关研究进展进行论述。
Neurotransmission begins with neurotransmitter being released from synaptic vesicles. To achieve this function, synaptic vesicles endure the dynamic ＂release-recycle＂ process to maintain the function and structure of presynaptic terminal. Among them, vesicle recycling is the basis of synaptic vesicle cycling. Studies show that clathrin mediated endocytosis is a major pathway of vesicle recycling, in which Dynamin plays an important role. Dynamin is a GTP ases with molecular weight of 100 kD, which acts as ＂scissors＂ in the endocytosis, separating the clathrin coated pits from membrane. In this paper, we discussed the modesof synaptic vesicle recycling, the mechanism of Dynamin and the influence of endocytic process after regulating dynamin.
出处
《中国医学文摘（耳鼻咽喉科学）》
2017年第6期368-371,共4页
Chinese Medical Digest(Otorhinolaryngology)
基金
国家自然科学基金资助项目(81470694)
