摘要
大量使用有机磷和氨基甲酸酯类杀虫剂可导致蚊虫产生显著抗药性。抗性产生的重要原因之一是乙酰胆碱酯酶(AChE)对杀虫剂的敏感性下降,而根本原因是AChE基因突变。该文对AChE基因的结构特点、功能、活性位点及AChE基因改变与蚊虫抗药性关系的研究进行归纳概述,并对蚊虫AChE基因研究前景进行分析和展望。
Intensive use of organophosphate and carbamate insecticides has led to the development of resistance inmosquitoes. Acetylcholinesterase（AChE）insensitivity to organophosphate and carbamate insecticides has been identifiedas a major resistance mechanism in mosquitoes. This paper reviewed the progress of AChE gene mutations associated withinsecticide resistance in mosquitoes. The AChE structure characteristics, the functional sites of AChE genes and the effectof mutation on insecticide resistance were detailed. Finally, the prospects in the studies of mosquito AChE were analyzed.
出处
《中国媒介生物学及控制杂志》
CAS
2017年第6期608-611,共4页
Chinese Journal of Vector Biology and Control
基金
国家自然科学基金(81271876
81471985
81672059)
山东省自然科学基金(ZR2015YL023)
山东省高等学校科技发展计划(J13LK12)
山东省高等学校青年骨干教师国内访问学者项目
山东省高校优秀科研创新团队计划~~
关键词
蚊虫
抗药性
乙酰胆碱酯酶
基因突变
Mosquitoes
Insecticide resistance
Acetylcholinesterase
Gene mutation
