摘要
健康肠道由共生菌群、上皮层和肠道相关淋巴组织（GALT）构成.GALT具有识别并处理相关的病原体的能力,而对共生菌和饮食抗原具有低反应性.现有证据表明,树突状细胞（den-dritic cells,DC）在处理这种异常的情况并且维持肠道复杂的稳态时起到了决定性的作用.在肠道上皮细胞（IECs）和共生菌群的影响下,肠道DC具有独特的功能,它在稳定状态下可以对Th2细胞、调节性T细胞和IgA进行精密的调节.感染时,它们参与效应淋巴细胞的诱导,但它们在炎症性肠病（IBD）时也会引发致病反应.这关系到机体对共生菌免疫耐受性的维持,以及抵御病原体时保护性免疫应答的产生.这篇综述概括了肠道共生菌群、上皮层和GALT在黏膜稳态、炎症状态和现阶段我们理解的DC在参与肠道稳态调节中的作用.
A healthy gut consists of commensal flora,epithelial layer and gut-associated lymphoid tissue （GALT）. GALT is hyporesponsive to commensal flora and dietary antigens,but can recognize and at-tack pathogens. Accumulating evidence suggests that dendritic cells （DCs） play a crucial role in managing this paradoxical situation and maintaining the complex homeostasis in gut. Influenced by intestinal epithelial cells （IECs） and commensal flora,intestinal DCs possess unique properties that enable them to regulate T-helper 2 （Th2） cells,regulatory T cells （Tregs） and immunoglobulin A （IgA）-producing cells in a steady state. During infection,intestinal DCs are involved in the induction of effector lymphocytes, although they are also responsible for initiating pathogenic responses in inflammatory bowel diseases （IBDs）. Therefore, intestinal DCs are associated with not only the maintenance of immune tolerance to commensal flora,but also the induction of protective immune responses against pathogens. This review outlines the roles of commensal flora, epithelial layer, and GALT in mucosal homeostasis and inflammation and summarizes recent progress in DCs-mediated intestinal immune homeostasis.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2017年第10期802-804,共3页
Chinese Journal of Microbiology and Immunology
基金
国家自然科学基金（81172882）
关键词
共生菌
肠道上皮细胞
树突状细胞
免疫稳态
Commensal flora
Intestinal epithelial cell
Dendritic cell
Immune homeostasis
