摘要
新生儿脓毒血症(neonatal sepsis,NS)是新生儿期的危重症,发病率为1~10/1000活产儿,病死率1%~70%不等,存在区域差异及不同新生儿人群特点;NS病原菌谱呈现动态变迁,目前凝固酶阴性葡萄球菌为新生儿重症监护室分离出的最常见的病原菌,非B族溶血性链球菌的病原体引发的早发型NS的发生率有所上升;NS临床特点是非特异性症状及个体化临床表现,常易被漏诊和误诊;近年来NS的检查方法和治疗措施存在的新研究进展,可以为NS的早期诊断和精确治疗提供帮助;早产儿、低出生体重儿及其母亲感染性疾病的新生儿是防治NS需关注的高危人群;NS相关的医院感染控制方法及管理策略是未来研究重点之一;多学科研究结果需在统一的诊断标准下进行整合,持续推进临床NS诊断治疗技术的进步。
Neonatal septicemia（NS）was one of the major causes of morbidity and mortality during the neonatal period.The incidence of NS was 1~10 per 1000 live births and the mortality of NS was 1%to 70%in different regions or neonatal populations.Pathogens spectrum has shown its dynamic transition process.Coagulase negative Staphylococcus was the most common pathogens isolated from neonatal intensive care unit.The incidence of nonStreptococcus agalactiae pathogens caused early-onset NS was on the rise.Clinical manifestations of NS were not specific,so it was often misdiagnosed.Recent progress in diagnosis and treatment of NS could provide useful information for early diagnosis and accurate treatment of NS.More attention related to prevention and treatment of NS should be paid to the high-risk groups,including preterm newborns,low birth weight newborns and newborns whose mothers were with infectious diseases.Hospital infection control methods and management strategies related to NS were the focuses of future researches.The integration of multidisciplinary research results under the unified diagnostic criteria would constantly promote progress in clinical diagnosis and treatment of NS.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第24期5745-5750,共6页
Chinese Journal of Nosocomiology
