摘要
目的通过检测P450arom在子宫腺肌病（adenomyosis，AM）异位、原位及正位内膜组织中的表达，进一步探讨AM的发病机制。方法采用免疫组化染色SP法，对129例手术切除经病理证实为AM的标本组织中，P450arom进行检测，并用SPSS17.0软件包进行分析。结果异位内膜、原位内膜及正位内膜组织中P450arom表达阳性率分别为46.94%、67.35%、19.35%，平均秩和分别为66.40、76.67、44.34，三组之间差异有统计学意义（χ^2＝17.012，P＝0.000）。结论子宫腺肌病患者的原位内膜可使腺体向肌层浸润，异位内膜局部高雌激素状态可能促进异位子宫内膜在子宫肌层的生长。
Objective To investigate the expression of P450arom in ectopic, situ and normal endometrial tissues of the adenomyosis （ AM）, and to investigate the pathogenesis of adenomyosis. Methods The SP method was used to detect the P450arom in 129 cases of surgical resection and cases of surgical resection. The SPSS17.0 software package was used to analyze the results. Results The expression of P450arom in ectopic endometrium,eutopic endometrium and normal endometrium positive rate were 46.94%, 67.35%, 19.35%, and the average rank were 66.40,76.67,44.34, there was significant difference between three groups ,χ^2 = 17. 012,P = 0. 000. Conclusion In the patients with uterine gland disease, the in situ endometrium may make the gland to the muscle layer infiltration, ectopic endometrial local high estrogen status may promote the growth of ectopic endometrium in the uterine muscle layer.
作者
杨玉敏
Yang Yumin(Gynaecology of Xiamen , Hospital of Traditonal Chinese Medicine ,Xiamen 361009, China)
出处
《国际免疫学杂志》
CAS
2017年第6期638-640,共3页
International Journal of Immunology
