摘要
目的:探讨血管性痴呆患者凋亡抑制蛋白Livin、干扰素(IFN)-γ与血流动力学的变化及其临床意义。方法:随机选择在我院进行治疗的血管性痴呆患者164例,使用简易智能量表(MMSE)对所有患者的智力进行评估,测定Livin、IFN-γ水平;同时统计患者饮食干预、中药调剂、家族病史等一般因素,以病情评估结果为因变量,采用Logistic回归分析经筛选因素与病情评估结果的关系。结果:不同性别之间的Livin、IFN-γ及血流动力学测量结果无显著差异(P均>0.05);Logistic回归分析显示,IFN-γ、血流动力学、家族病史、吸烟、酗酒、年龄及病程均为血管性痴呆的危险因素(B=0.351~3.041,P均<0.01),而Livin、饮食干预、中药调剂和病后运动干预均为血管性痴呆的保护因素(B=-1.224^-2.547,P均=0.001)。Livin、IFN-γ、血流动力学的权重较高(分别为-2.547、2.641、1.477),对认知功能水平有较强影响。结论:血管性痴呆患者的Livin、IFN-γ及血流动力学对其认知功能有一定影响,对上述项目进行检查,并进行适当的心理及生理干预,有助于改善预后。
Objective.. To explore inhibitor of apoptosis protein--Livin, interferon （IFN） -y and hemodynamic chan- ges in patients with vascular dementia and their clinical significance. Methods.. A total of 164 patients with vascular dementia treated in our hospital were randomly selected. All patients＂ mentality were assessed by mini-mental state examination （MMSE）, and levels of Livin and IFN-3＇ were measured; meanwhile, general factors such as diet inter- vention, traditional Chinese medicine therapy and family history etc., were counted. With outcome of patients＂ condition assessment as dependent variable, Logistic regression was used to analyze the relationship among all screened factors and outcome of patient＂ condition assessment. Results： There were no significant difference in measured outcomes of Livin, IFN-7 and hemodynamics between men and women, P〈0.05 all; Logistic regression analysis indicated that IFN-7, hemodynamics, family history, smoking, alcoholism, age and course of disease were risk factors for vascular dementia （B = 0. 351-3. 041, P〈0.01 all）, and Livin, diet intervention, traditional Chi- nese medicine therapy and exercise intervention after onset were protective factors for vascular dementia （B = - 1. 224 - 2.547, P = 0. 001 all）. Livin, IFN-7 and hemodynamics possessed higher weights （B was - 2. 547, 2. 641 and 1. 477 respectively）, who had stronger influence on cognitive function level. Conclusion： Livin, IFN-7 and hemodynamics have certain influence on cognitive function reduction in patients with vascular dementia. Exami- nation of above indexes and certain psychological and physiological intervention can help to improve prognosis.
出处
《心血管康复医学杂志》
CAS
2017年第6期597-601,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
痴呆
血管性
血流动力学
干扰素
γ
Dementia, vascular
Hemodynamics
Interferon-gamma
