摘要
目的探讨高龄老年人强化降脂与心血管事件发生的相关性,以及对脑卒中患者生活质量的影响,为高龄老年人强化降脂的合理应用提供临床证据。方法选取≥75岁高龄老年人723例,其中患有脑卒中者179例,无脑卒中者544例;降脂达标组189人,未达标组534人。收集相关病史、肝功能、血脂等指标。结果降脂达标组发生心血管事件比例小于未达标组,差异有统计学意义(P<0.001);对于患脑卒中者,降脂达标组的改良Rankin评分(m RS)明显低于未达标组,差异有统计学意义(P=0.002)。结论高龄老年人强化降脂治疗有预防心血管事件发生的作用,且高龄老年脑卒中患者强化降脂治疗有更好的生活质量。
Objective To evaluate the relationship between low-density lipoprotein cholesterol（LDL-C）reduction therapy and major adverse cardiovascular events（MACE;myocardial infarction,stroke and vascular death）in elderly patients,to assess the effect of LDL-C reduction therapy in patients with stroke on life quality and to obtain clinical evidence of LDL-C reduction therapy in elderly patients. Methods A total of 723 patients over the age of 75 years old were selected for the study. The patients were divided into two groups, patients with stroke（n=179）or non-stroke patients（n=544）,and were also subdivided into two groups：reached the LDL-C goal of 1.80 mmol/L（n=189） and unreached LDL-C goal（n=534）. Their serum levels of LDL-C were measured,and their levels of alanine aminotransferase（ALT） were tested. Results The rate of occurred MACE was lower in patients who reached the LDL-C goal than the unreached patients（P〈0.001）. In the group with stroke,neurological function（m RS）was better in the reached group compared with the unreached（P=0.002）. Conclusion LDL-C reduction therapy in elderly patients is effective and can improve the life quality in patients with stroke.
出处
《中华保健医学杂志》
2017年第6期502-504,共3页
Chinese Journal of Health Care and Medicine
