摘要
力学因素对于细胞的结构和功能起着重要的调节作用,细胞异常的力学响应可能会导致一系列的病理变化.由于眼压等多种因素的影响,眼部细胞处于不断变化的动态力学环境中,其产生的力学效应在眼内多种组织结构的病理生理过程中发挥重要的作用.本文综述了近年来眼的角膜细胞、巩膜细胞、小梁网细胞、筛板区细胞、视网膜细胞等的力生物学研究进展,从力生物学角度讨论相关疾病可能的发病机制,以提供新的预防和诊疗思路.
Mechanical factor plays an important role in regulating cellular function and structure.The abnormal mechanical response of cell may lead to a series of pathological changes.Due to the influence of intraocular pressure and other factors,the ocular cells are in a dynamic mechanical environment.The effects of different types of mechanical stimuli on ocular cells attribute to both the physiology and pathology of various ocular tissues.This paper summarized the progress of mechanobiology research of corneal cells,scleral cells,trabecular meshwork cells,cells in the lamina cribiosa region and retinal cells,and discussed the possible pathogenesis of related ocular diseases from biomechanical aspect,in order to provide new ideas for disease prevention,diagnosis and treatment.
出处
《国际眼科纵览》
2017年第5期305-311,共7页
International Review of Ophthalmology
基金
国家自然科学基金（11402017）
北航蓝天新秀基金（ZG216S17C4）
关键词
眼部细胞
力生物学
ocular cell
mechanobiology
