摘要
目的研究并探讨促性腺激素释放激素激动剂(gonadotropin releasing hormone-agonist,GnRH-a)对子宫内膜异位症患者行腹腔镜手术后的氧化应激状态、症状缓解率以及复发率的影响。方法选取2015年10月至2016年12月于深圳市龙华区中心医院行腹腔镜手术并接受术后随访的100例子宫内膜异位症患者为研究对象,根据随机数字表法将其分为观察组(50例)和对照组(50例)。术后,观察组患者皮下注射GnRH-a进行治疗,对照组患者口服孕三烯酮进行治疗。检测并对比两组患者在治疗前及连续治疗3个月后的活性氧(reactive oxygen species,ROS)、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)以及血浆谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)的水平,比较两组患者随访1年的临床症状缓解率和复发率。结果两组患者治疗前的血清ROS、MDA、SOD以及GSH-Px浓度比较,差异无统计学意义(P>0.05);治疗3个月后两组的ROS和MDA浓度降低,SOD以及GSH-Px浓度明显升高,观察组各项指标改善情况优于对照组,差异有统计学意义(P<0.05)。随访1年,观察组的临床症状缓解率以及复发率情况优于对照组,但差异无统计学意义(P>0.05)。结论 GnRH-a能够有效改善子宫内膜异位症患者行腹腔镜术后的氧化应激状态,提高患者治疗效果,降低复发率,提高生活质量,值得临床推广。
Objective To study and diseuss effect of gonadotropin releasing hormone agonist （GnRH -a） on oxidative stress status, symptom remission rate and recurrence rate of patients with endometriosis after laparoscople surgery. Methods 100 cases of patients with endometriosis treated with laparoseopic surgery and followed - up in Central Hospital of Longhua District of Shenzhen City from October 2015 to December 2016 were selected , the patients were divided into the observation group（50 cases） and the control group （50 cases） according to the random number table. After surgery, patients of the observation group were treated with subcutaneous injection of GnRH - a, and patients of the control group were treated with oral administration of gestrinone. The levels of reactive oxygen species（ ROS）, malondialdehyde （ MDA）, superoxide dismutase （SOD） and plasma glutathione peroxidase （ GSH - Px） of patients before and after 3 months＇ treatment were detected and compared. At the same time, the clinical symptom remission rate and recurrence rate of patients of the two groups were recorded during the follow - up period of one year. Results There were no statistical differences in serum ROS, MDA, SOD and GSH - Px concentrations before treatment between the two groups. After 3 months＇ treatment, the ROS and MDA concentrations of patients of the two groups decreased, SOD and GSH - Px concentrations were significantly increased. The improvement of the observation group was better than that of the control group. The differences were statistically significant（P 〈 0. 05）. The clinical symptom remission tale and recurrence rate of patients of the observation group were better than those of the control group one year after treatment, but the differences were not significant（P 〉 0. 05 ）. Conclusion GnRH - a can effectively improve the oxidative stress of patients with endometriosis after laparoscopic surgery, improve the treatment effect and reduce the recurrence rate, improve the quality of life
出处
《中国计划生育和妇产科》
2017年第12期53-56,共4页
Chinese Journal of Family Planning & Gynecotokology
