摘要
目的探讨替加环素对多重耐药鲍曼不动杆菌腹腔感染的临床疗效。方法回顾性分析2012年6月—2017年10月共52例患者多重耐药鲍曼不动杆菌腹腔感染的临床资料,其中26例患者使用替加环素(试验组),26例患者使用亚胺培南/西司他丁治疗(对照组),观察及比较两组间临床有效率、细菌清除率、不良反应以及治疗前后主要炎症指标白细胞计数(WBC)、C-反应蛋白(CRP)、降钙素原(PCT)的变化情况。结果试验组临床有效率、细菌清除率均优于对照组,主要炎症指标两组治疗后均呈下降趋势,且试验组下降更为明显(P<0.05)。而不良反应两组差异无统计学意义(P>0.05)。结论替加环素对多重耐药鲍曼不动杆菌腹腔感染具有较好的临床疗效。
Objective To investigate the clinical effect of tegacycline on multidrug-resistant Acinetobacter Baumannii intraperitoneal infection. Methods The clinical data of 52 patients with multiple drug resistance of Acinetobacter Baumannii from June 2012 to October 2017 were analyzed retrospectively. 26 patients were treated with tegocycline （test group）, and 26 patients were treated with imipenem / eelastatin （control group）. The clinical effective rate, bacterial clearance rate, adverse reactions and the changes of main inflammatory indexes, white blood cell count （WBC）, Creactive protein （CRP） and procalcitonin （PCT） in the two groups before and after treatment were observed and compared. Results The clinical efficiency and bacterial clearance rate of the test group were all better than those of the control group. The main inflammatory indicators in the two groups were decreased after treatment, and the decrease in the experimental group was more obvious （P 〈 0.05）. There was no significant difference between the two groups of adverse reactions （P 〉 0.05）. Conclusion Tegacycline has a good clinical effect on multidrug-resistant Acinetobaeter Baumannii intraperitoneal infection.
出处
《中国卫生标准管理》
2017年第27期89-92,共4页
China Health Standard Management
