摘要
慢性阻塞性肺疾病(COPD)是世界范围内导致残疾和死亡的主要原因之一。COPD不仅是一种呼吸道炎症疾病,也是一种伴许多肺外表现的全身性慢性炎症。在COPD急性加重期(AECOPD)滥用抗生素是临床工作中的一个重要难题,从而导致治疗费用增加及超级细菌的产生。降钙素原和C反应蛋白是重要的炎症标志物,在早期诊断AECOPD是否存在细菌感染方面具有很高的特异性和敏感性,并对其指导抗菌药物使用具有重要的临床意义。
Chronic obstructive pulmonary disease （COPD） is one of the leading causes of disability and death world-wide. COPD is not only a respiratory inflammatory condition, but also a mild chronic systemic inflammation accompanied by many extrapulmonary manifestations. In patients with acute exacerbation of COPD （ AECOPD）, there is excessive use of antimierobial drugs, which is a serious problem in clinical practice, resulting in increased treatment costs and the production of super bacteria. Procalcitonin and C-reactive protein are important inflammatory markers, which have high specificity and sensitivity to early diagnosis of bacterial infection, and has great clinical significance to guide the antimicrobial drug use.
出处
《医学综述》
2017年第24期4846-4850,共5页
Medical Recapitulate
基金
上海市卫生和计划生育委员会科研课题计划(201440060)
关键词
慢性阻塞性肺疾病
降钙素原
C反应蛋白
细菌感染
脓性痰
Chronic obstructive pulmonary disease
Procalcitonin
C-reactive protein
Bacterial infection
Purulent sputum
