摘要
目的:通过分析初诊原发性高血压患者血压变异性(BPV)与尿微量白蛋白(MA)的关系,探讨BPV评价指标:平均实际变异(ARV)和标准差(SD)的优劣。方法:选取223例初诊原发性高血压患者,根据MA结果分为阳性组和阴性组,分别为71例和152例。比较两组基线资料、24h平均收缩压与舒张压、夜间收缩压与舒张压、白天收缩压与舒张压及相应时间段的SD和ARV,分析MA与年龄、平均血压、SD、ARV等的相关关系。结果:MA阳性组平均收缩压(24h、夜间、白天)、收缩压SD(24h、白天、夜间)、收缩压ARV(24h、白天)均高于MA阴性组,且有统计学意义(P<0.05);Logistic回归分析表明,24h平均收缩压、白天收缩压SD、夜间收缩压SD、24h收缩压ARV是MA的独立危险因素。结论:BPV是预测高血压早期肾功能损害的独立危险因素,SD、ARV均可以较好的评价BPV。
Objective: To investigate the relationship of BPV evaluation index: the actual average variation( ARV) and standard deviation( SD) of the pros and cons through the analysis of newly diagnosed patients with essential hypertension blood pressure variability( BPV) and urinary albumin( MA). Method: A total of 223 of primary hypertension patients were selected,averaged( 50.9±12.1) years old. all the patients were not taking antihypertensive drugs,according to microalbuminuria divided into positive-MA group( 71 case) and negative-MA group( 152 case). Baseline data,24 h mean systolic and diastolic pressure,nocturnal systolic and diastolic blood pressure,daytime systolic and diastolic blood pressure,and SD and ARV of the corresponding period were compared,to analyze the relationship between MA and mean blood pressure,SD,ARV,and so on. Result: The SD( 24 h SBP,d SBP,n SBP),ARV( 24 h SBP,d SBP) in positive-MA group were higher than the negative-MA group,and there was statistical significance( P <0.05); but SD,ARV of diastolic blood pressure,ARV of nighttime systolic blood pressure are no significant difference between the two groups( P >0.05).(2)Logistic regression analysis showed that 24 h mean systolic blood pressure,SD of diurnal systolic pressure,SD of nocturnal systolic blood pressure,ARV of 24 h systolic blood pressure were independent risk factors of MA. Conclusion: Blood pressure variability is an independent risk factor for predicting early renal function impairment,and SD and ARV can be used to assess blood pressure variability.
出处
《河北医学》
CAS
2017年第12期2061-2065,共5页
Hebei Medicine
基金
安徽省软科学研究项目
(编号:12020503078)
关键词
高血压
血压变异性
尿微量白蛋白
平均实际变异
Essential hypertension
Blood pressure variability
Microalbuminuria
Average real variability
