摘要
在倡导精准医疗的今日,在基本掌握与肿瘤发生密切相关的靶点的机理后,如何实现肿瘤靶向治疗,尽量消减由治疗带来的不良反应显得尤为关键。核酸适配子是能与靶标以高亲和力、高特异性结合的寡核苷酸;无机纳米材料是纳米材料作为医学领域诊疗制剂中重要的组成部分;利用核酸适配子与靶标结合的特性将其与无机纳米材料结合后,可将靶向结合、生物成像及药物递送等特点集于一体,综合应用于肿瘤研究,同时有力于促进核酸纳米技术的发展。综述了近年不同无机纳米材料结合核酸适配子在肿瘤研究领域中的研究进展,以及对无机纳米材料在医学应用的安全性思考,以期早日实现新型靶向肿瘤治疗策略的开发。
At nowadays in the promotion of precise medical treatment,how to achieve tumor targeted therapy and reduce the side-effectsof radiotherapy is particularly critical after we understood the mechanism of the key molecular targets closely related to tumorigenesis. Aptamersare single-stranded DNA or RNA oligonucleotides which can bind with various targets at high affinity and specificity. Inorganic nanomaterial isan important part of nanomaterial as a medical diagnosis and treatment preparation. Taking the advantage of the properties of aptamers bindingwith their targets at high affinity,the system of their binding with inorganic nanomaterial can be applied in the tumor research in an integratedapproach of targeted binding,biological imaging and drug delivery,concurrently which efficiently promotes the development of nucleic acidnanotechnology. In this review,we discuss the application of varied inorganic nanomaterial binding with the aptamers in tumor research andthe safety of inorganic nanomaterial in medical applications,aiming at earlier achieving the development of new targeted therapy strategies totumor.
出处
《生物技术通报》
CAS
CSCD
北大核心
2017年第11期48-53,共6页
Biotechnology Bulletin
基金
国家自然科学基金项目(81272509
81471388)
广东省自然科学基金项目(2014A030313351)
