摘要
[目的]通过比较酒精性股骨头坏死患者和健康人,探索酒精性股骨头坏死风险因素的血液生化指标。[方法]本研究经过回顾性筛选2012年3月~2015年10月本院收治的酒精性股骨头患者156例,其中16例因合并肿瘤或结核被排除,最终纳入140例作为坏死组。自本院检验中心数据库中抽取140例健康人作为对照组。对纳入的各组生化指标进行单因素方差分析并进行Students t检验,筛选出有统计学意义的指标。将有统计学意义指标的95%CI与正常范围进行对比,筛选出超过正常范围的相关指标定义为风险因素。将风险因素进行相应的赋值并进行逐步logistic回归分析得出结论。[结果]坏死组患者体内CO_2CP,CHOL,TG,HDL,LDL其偏回归系数具有统计学意义,回归方程具有明显统计学意义。CO_2CP(下降),CHOL(升高),TG(升高),HDL(下降),LDL(升高)是酒精性ONFH发生的强风险因素,其Odds Ratio值分别为:19.36、66.56、97.66、74.37、22.92。[结论]血生化指标中CO_2CP(下降),CHOL(升高),TG(升高),HDL(下降),LDL(升高)是酒精性ONFH发生的强风险因素。对于酗酒的人群,可以对其血生化情况进行检查,作为筛查酒精性股骨头坏死高风险人群手段。
[Objective] To explore the risk factors of alcoholic osteonecrosis of the femoral head （ONFH） from blood biochemical markers by comparison of the patients with the healthy persons. [Methods] A retrospective study was conducted on 156 patients with alcoholic femoral head who were admitted to our hospital from March 2012 to October 2015. Of them, 16 patients were excluded from this study for tumor or tuberculosis, and the remaining 140 patients were included. Other 140 normal patients were selected as the control from the Physical Examination Center database. One-way analysis of variance and Student＇s t test was used to screen the biochemical markers with significant difference to the health. The variables beyond the normal range were screened out and defined as potential risk factors. Finally, the risk factors were further evaluated by Stepwise logistic regression. [Results] The CO2CP （OR=19.36, P〈0.001）, CHOL （OR=66.56, P〈0.001）, TG （OR=97.66, P〈0.001）, HDL（OR= 74.37, P〈0.001） and LDL （OR=22.92, P〈0.001） showed statistically significances in the regression equation, which indicated that CO2CP （down）, CHOL （rise）, TG （high）, HDL （down）, LDL （rise） were strong risk factors for alcoholic ONFH. [Conclusion] CO2CP （decreased）, CHOL （elevated）, TG （elevated）, HDL （decreased）, LDL （elevated） are strong risk factors for the occurrence of alcoholic ONFH. For alcohol abuse individual, blood biochemical tests can be carried out to screen out the risk of alcohol induced osteonecrosis of the femoral head.
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2017年第23期2177-2181,共5页
Orthopedic Journal of China
关键词
ONFH
血液生化
血脂异常
逻辑回归
osteonecrosis of the femoral head, blood biochemistry, dyslipidemia, logistic regression
