摘要
目的探讨超敏C反应蛋白、血清同型半胱氨酸与产后抑郁的相关性。方法自2015年1月-2016年1月,连续性收集在该院分娩的孕产妇382例,其中共52例孕产妇发生抑郁,分析血清超敏C反应蛋白、同型半胱氨酸与产后抑郁的相关性。结果与对照组比较,抑郁组超敏C反应蛋白水平显著增高,差异有统计学意义[(7.47±2.88)mg/L vs.(5.38±2.43)mg/L,t=5.614,P<0.05];同型半胱氨酸水平显著增高,差异有统计学意义[(11.82±4.28)mmol/L vs.(8.17±3.19)mmol/L,t=7.288,P<0.05]。多因素logistics回归分析显示超敏C反应蛋白≥10 mg/L、同型半胱氨酸≥10 mmol/L是孕产妇产后抑郁的危险因素(P<0.05)。多元线性回归分析显示超敏C反应蛋白和同型半胱氨酸水平可影响爱丁堡产后抑郁评分(P<0.05)。结论超敏C反应蛋白、同型半胱氨酸水平升高是产后抑郁的危险因素,且与产后抑郁严重程度正相关。
Objective To explore the correlations between serum high-sensitivity C-reactive protein （hs-CRP）, homocysteine and postpartum depression. Methods From January 2015 to January 2016, a total of 382 pregnant women were collected continuously from the Third Penple＇s Hospital of Ningxi, including 52 pregnant women with postpartum depression. The correlations between serum hs-CRP, ho- mocysteine and postpartum depression were analyzed. Results The level of serum hs-CRP in postpartum depression group was （7.47±2. 88）mg/L, which was statistically significantly higher than that in control group [ （5.38±2.43） mg/L] （t = 5. 614, P〈0.05） . The lev- el of serum homocysteine in postpartum depression group was （11. 82±4. 28 ） mmol/L, which was statistically significantly higher than that in control group [ （8. 17±3. 19） mmol/L] （t=7. 288, P〈0. 05） . Multivariate logistic regression analysis showed that hs-CRP≥10 mg/L and homocysteine≥10mmol/L were risk factors of postpartum depression （P〈0. 05） . Multivariate linear regression analysis showed that the levels of hs-CRP and homocysteine affected the score of Edinburgh Postnatal Depression Scale （P〈0. 05） . Conclusion The increases of hs-CRP and homocysteine levels are risk factors of postpartum depression, which are positively correlated with the severily of postpartum depression.
出处
《中国妇幼保健》
CAS
2017年第23期5881-5884,共4页
Maternal and Child Health Care of China
关键词
产后抑郁
超敏C反应蛋白
同型半胱氨酸
爱丁堡产后抑郁评分
Postpartum depression
High-sensitivity C-reactive protein
Homncysteine
Edinburgh Postnatal Depression Scale score
