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检测Notch3、Lgr5、NF-kB在大肠腺癌组织中表达情况的意义

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摘要 目的:探讨检测Notch3、Lgr5(富含亮氨酸重复序列G蛋白偶联受体5)、NF-k B(核转录因子KB)在大肠腺癌组织中表达情况的意义。方法 :检测50例大肠腺癌患者癌组织中Notch3、Lgr5、NF-k B的MOD(光密度)值,然后对比这三个指标在不同大肠腺癌病理组织中的MOD值。结果:Notch3、Lgr5、NF-k B在浸润T3+T4中、Dukes分期C+D中、存在淋巴结转移的癌组织中的MOD值高于其在T1+T2中、Dukes分期A+B中、不存在淋巴结转移的癌组织中的MOD值,差异具有统计学意义(P<0.05)。结论 :Notch3、Lgr5、NF-k B在浸润T3+T4中、Dukes分期C+D中、存在淋巴结转移的癌组织中存在高表达的状态。
出处 《当代医药论丛》 2017年第20期38-39,共2页
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