摘要
长链脂肪酸受体GPR120属于G蛋白偶联受体GPCRs中的一员,也称为3FAR1或ω3脂肪受体1,因其是游离长链不饱和脂肪酸受体,在多种生理生化反应中都有着至关重要的作用。它不仅可以调节胃肠道激素分泌、脂肪细胞发育和分化,促进细胞增殖,介导抗炎症作用,还与肥胖和糖尿病等代谢疾病的发生密切相关。作为当下研究热点,其激动剂的研究也是非常活跃的领域。文章主要就近来GPR120受体的研究现状及其有关的新药研发做一综述。
Long chain fatty acid receptor GPR120 belongs to G protein receptor GPCRs,also known as O3 FAR1 or ω3 fatty receptor1. Since it is free long chain unsaturated fatty acid receptor,so it has a vital role in the physiological and biochemical reaction. It can not only regulate the secretion of gastrointestinal hormones,adipose cell development and differentiation,promote cell proliferation and mediate antiinflammatory effect,but also it is closely related with obesity,diabetes and other metabolic diseases. As the current research focus,the agonist research is also very active in the field. This paper focuses on the research status of GPR120 receptors and the development of new drugs in recent years.
出处
《药物生物技术》
CAS
2017年第5期459-463,共5页
Pharmaceutical Biotechnology
关键词
GPR120受体
长链脂肪酸
激动剂
生理学功能
新药开发
GPR120 receptor, Long chain fatty acid, Agonist, Physiological function, New drug development
