摘要
环胞苷二棕榈酸酯在体内可被酯水解酶作用,释放出活性成分,是环胞苷的前体药物,选择脂质体做为此药的载体,与游离药物比较,动物吸收好,抗癌活性提高1.5倍,分解失效减缓,有效期延长3倍。显示出脂质体适于脂溶性药物载体的优越性。
Dipalmitoyl cyclocytidine (DPC), the prodrug of cyclocytidine, was hydrolysized in uivo by en-zyme and parent drug was released. With liposomesas a carrier of DPC, the antitumor activity andchemical stability were compared between free DPCand DPC liposomes. The results showed that lipo-somes improved antitumor activity and uptake ofencapsulated prodrug. The shelf-life of DPC in lipo-somes was delayed 4 times that of free DPC. Theadvantages of liposomes suitable for liposolubledrugs were evident.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1991年第11期661-663,共3页
Chinese Pharmaceutical Journal
基金
自然科学基金
