摘要
目的探讨参松养心胶囊对慢性心力衰竭合并室性心律失常患者血流动力学的影响。方法选择于2013年8月至2016年1月在该院接受诊疗的慢性心力衰竭合并室性心律失常患者126例作为研究对象进行前瞻性研究。将前63例入院患者设置为观察组,后63例患者设置为对照组。对照组患者常规西药治疗,观察组在对照组基础上给予参松养心胶囊治疗,两组均治疗8周。比较两组疗效、血流动力学等情况。结果治疗后对照组患者总有效率85.7%明显低于观察组的96.8%(P<0.05)。两组患者治疗前后的平均动脉压(MAP)都在正常范围内,差异无统计学意义(P>0.05)。治疗后观察组患者左心室舒张期内径(LVDd)和左心室收缩期内径(LVDs)明显高于对照组(P<0.05),且两组治疗后均明显高于治疗前(P<0.05)。两组患者治疗后QTcd明显低于治疗前(P<0.05),观察组降低更明显(P<0.05)。结论参松养心胶囊治疗慢性心力衰竭合并室性心律失常不会导致血流动力学的异常,促进心功能的改善,发挥抗心律失常作用,提高疗效。
Objective To study the effect of Shensongyangxin Capsule on hemodynamics in the patients with chronic heart failure complicating ventricular arrhythmia.Methods A total of 126 patients with chronic heart failure complicating ventricular arrhythmia treated in this hospital from August 2013 to January 2016 were selected as the study subjects for conducting the prospective study.The former 63 cases served as the observation group and the latter 63 cases as the control group.The control group were treated with conventional Western medicines.On the basis of the control group,the observation group was auxiliarily given Shensongyangxin Capsule.Both groups were treated for 8 weeks.The curative effects and hemodynamics were compared between the two groups.Results The total effective rate in the control group was 85.7%,which was significantly lower than 96.8%in the treatment group（P〈0.05）.The central artery pressure（MAP）was in the normal range before and after treatment in two groups,the difference between the two groups had no statistical significance（P〈0.05）.The LVDd and LVDs values after treatment in the observation group were significantly higher than those in the control group（P〈0.05）,and the LVDd and LVDs values after treatment in the two groups were significantly higher than those before treatment（P〈0.05）.The QTcd values after treatment in the observation group and control group were significantly lower than those before treatment（P〈0.05）,the QTcd values after treatment in the observation group were significantly lower than those in the control group（P〈0.05）.Conclusion Shensonyangxin Capsule in the treatment of chronic heart failure complicating ventricular arrhythmia does not lead to the hemodynamic abnormalities,promotes the heart function improvement and plays the antiarrhythmic effect and increases the curative effect.
出处
《重庆医学》
CAS
北大核心
2017年第33期4647-4649,4652,共4页
Chongqing medicine
基金
2012年海南省自然科学基金资助项目(812147)
