摘要
目的研究同步调强放化疗联合生脉注射液治疗鼻咽癌的近期疗效、不良反应和生活质量。方法51例初治鼻咽癌患者随机分为治疗组和对照组,治疗组患者给予同步调强放化疗联合生脉注射液治疗,对照组患者给予同步调强放化疗治疗。观察患者的近期疗效和不良反应,应用SF-36量表评估患者生活质量。结果放疗至50 Gy时和放疗结束时,治疗组鼻咽部肿瘤CR率(%)与对照组比较差异无统计学意义(P>0.05)。两组恶心/呕吐、口干、黏膜炎、皮肤炎不良反应发生率无显著性差异(P>0.05)。治疗组血红蛋白减少、白细胞减少、血小板下降Ⅰ/Ⅱ级发生率显著低于对照组(χ~2=4.777,P=0.029;χ~2=5.436,P=0.020;χ~2=5.436,P=0.020)。两组SF-36量表各项评分差异有统计学意义(P<0.05)。结论同步调强放化疗联合生脉注射液能够提高鼻咽癌患者近期疗效,减少不良反应,提高患者生活质量。
Objective To study the short-term efficacy,adverse reactions and life quality in patients with nasopharyngeal carcinoma treated with concurrent intensity-modulated radiotherapy and chemotherapy combined with shengmai injection.Methods51 cases of patients with nasopharyngeal carcinoma were randomly divided into the treatment group and the control group.Patients of the treatment group were treated with concurrent intensity-modulated radiotherapy and chemotherapy combined with shengmai injection,while patients of the control group were treated with concurrent intensity-modulated radiotherapy and chemotherapy.The short-term efficacy and adverse reactions were observed,and the life quality of patients were evaluated with SF-36 scale.Results There was no significant difference in the CR rate（%）between the treatment group and the control group（P0.05）at the end of radiotherapy to 50 Gy and the end of radiotherapy.There was no significant difference in the incidence of nausea/vomiting,dry mouth,mucositis and dermatitis between the 2 groups（P0.05）.The incidence of I/II adverse reactions of the treatment group,such as reduced hemoglobin,leukopenia,platelet descent were significantly lower than those of the control group（χ~2=4.777,P=0.029;χ~2=5.436,P=0.020;χ~2=5.436,P=0.020）.There was significant difference in SF-36 scale between the 2 groups（P0.05）.Conclusion Concurrent intensity-modulated radiotherapy and chemotherapy combined with shengmai injection can improve the short-term efficacy,reduce adverse reactions and improve the quality of life of patients with nasopharyngeal carcinoma.
出处
《实用癌症杂志》
2017年第12期1949-1952,共4页
The Practical Journal of Cancer
关键词
调强放疗
化学治疗
生脉注射液
鼻咽癌
concurrent intensity-modulated radiotherapy
chemotherapy combined
shengmai injection
intensity-modulated
radiotherapy
